Sequence of SQHC_ALIAD
EC Number:4.2.1.129
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
squalene-hopanol cyclase
P33247
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-IA)
631
71570
Reaction
hopan-22-ol = squalene + H2O
Other sequences found for EC No. 4.2.1.129
General information:
Sequence
0 MAEQLVEAPA YARTLDRAVE YLLSCQKDEG YWWGPLLSNV TMEAEYVLLC HILDRVDRDR
60 MEKIRRYLLH EQREDGTWAL YPGGPPDLDT TIEAYVALKY IGMSRDEEPM QKALRFIQSQ
120 GGIESSRVFT RMWLALVGEY PWEKVPMVPP EIMFLGKRMP LNIYEFGSWA RATVVALSIV
180 MSRQPVFPLP ERARVPELYE TDVPPRRRGA KGGGGWIFDA LDRALHGYQK LSVHPFRRAA
240 EIRALDWLLE RQAGDGSWGG IQPPWFYALI ALKILDMTQH PAFIKGWEGL ELYGVELDYG
300 GWMFQASISP VWDTGLAVLA LRAAGLPADH DRLVKAGEWL LDRQITVPGD WAVKRPNLKP
360 GGFAFQFDNV YYPDVDDTAV VVWALNTLRL PDERRRRDAM TKGFRWIVGM QSSNGGWGAY
420 DVDNTSDLPN HIPFCDFGEV TDPPSEDVTA HVLECFGSFG YDDAWKVIRR AVEYLKREQK
480 PDGSWFGRWG VNYLYGTGAV VSALKAVGID TREPYIQKAL DWVEQHQNPD GGWGEDCRSY
540 EDPAYAGKGA STPSQTAWAL MALIAGGRAE SEAARRGVQY LVETQRPDGG WDEPYYTGTG
600 FPGDFYLGYT MYRHVFPTLA LGRYKQAIER R
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
102553
Ochs D.,Kaletta C.,Entian K.-D.,Beck-Sickinger A.,Poralla K.
Cloning, expression, and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism.
J. Bacteriol.
174
298-302
1992
102555
Sato T.,Kanai Y.,Hoshino T.
Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites.
Biosci. Biotechnol. Biochem.
62
407-411
1998
102557
Ochs D.,Tappe C.H.,Gaertner P.,Kellner R.,Poralla K.
Properties of purified squalene-hopene cyclase from Bacillus acidocaldarius.
Eur. J. Biochem.
194
75-80
1990
102558
Wendt K.U.,Poralla K.,Schulz G.E.
Structure and function of a squalene cyclase.
Science
277
1811-1815
1997
102559
Wendt K.U.,Lenhart A.,Schulz G.E.
The structure of the membrane protein squalene-hopene cyclase at 2.0-A resolution.
J. Mol. Biol.
286
175-187
1999
