Sequence of GSK3B_RAT
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
60 VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
120 EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
180 DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDM
240 WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
300 WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF
360 NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT NAGDRGQTNN AASASASNST
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1065376
Woodgett J.R.
Molecular cloning and expression of glycogen synthase kinase-3/factor A.
EMBO J.
9
2431-2438
1990
1065377
Ishiguro K.,Shiratsuchi A.,Sato S.,Omori A.,Arioka M.,Kobayashi S.,Uchida T.,Imahori K.
Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.
FEBS Lett.
325
167-172
1993
1065378
Hughes K.,Nikolakaki E.,Plyte S.E.,Totty N.F.,Woodgett J.R.
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.
EMBO J.
12
803-808
1993
1065379
Ikeda S.,Kishida S.,Yamamoto H.,Murai H.,Koyama S.,Kikuchi A.
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
EMBO J.
17
1371-1384
1998
1065380
Chen H.J.,Lin C.M.,Lin C.S.,Perez-Olle R.,Leung C.L.,Liem R.K.
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.
Genes Dev.
20
1933-1945
2006
1065381
Mussmann R.,Geese M.,Harder F.,Kegel S.,Andag U.,Lomow A.,Burk U.,Onichtchouk D.,Dohrmann C.,Austen M.
Inhibition of GSK3 promotes replication and survival of pancreatic beta cells.
J. Biol. Chem.
282
12030-12037
2007
1065382
Timm T.,Balusamy K.,Li X.,Biernat J.,Mandelkow E.,Mandelkow E.M.
Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
J. Biol. Chem.
283
18873-18882
2008
1065383
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
