Sequence of PURK_ECOLI
EC Number:6.3.4.18
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
5-(carboxyamino)imidazole ribonucleotide synthase
P09029
Escherichia coli (strain K12)
355
39461
Reaction
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+ = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
Other sequences found for EC No. 6.3.4.18
General information:
Sequence
0 MKQVCVLGNG QLGRMLRQAG EPLGIAVWPV GLDAEPAAVP FQQSVITAEI ERWPETALTR
60 ELARHPAFVN RDVFPIIADR LTQKQLFDKL HLPTAPWQLL AERSEWPAVF DRLGELAIVK
120 RRTGGYDGRG QWRLRANETE QLPAECYGEC IVEQGINFSG EVSLVGARGF DGSTVFYPLT
180 HNLHQDGILR TSVAFPQANA QQQAQAEEML SAIMQELGYV GVMAMECFVT PQGLLINELA
240 PRVHNSGHWT QNGASISQFE LHLRAITDLP LPQPVVNNPS VMINLIGSDV NYDWLKLPLV
300 HLHWYDKEVR PGRKVGHLNL TDSDTSRLTA TLEALIPLLP PEYASGVIWA QSKFG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
977458
Tiedeman A.A.,Keyhani J.,Kamholz J.,Daum H.A. III,Gots J.S.,Smith J.M.
Nucleotide sequence analysis of the purEK operon encoding 5'-phosphoribosyl-5-aminoimidazole carboxylase of Escherichia coli K-12.
J. Bacteriol.
171
205-212
1989
977459
Watanabe W.,Sampei G.,Aiba A.,Mizobuchi K.
Identification and sequence analysis of Escherichia coli purE and purK genes encoding 5'-phosphoribosyl-5-amino-4-imidazole carboxylase for de novo purine biosynthesis.
J. Bacteriol.
171
198-204
1989
977461
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
977462
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
977463
Meyer E.,Leonard N.J.,Bhat B.,Stubbe J.,Smith J.M.
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
Biochemistry
31
5022-5032
1992
977464
Mueller E.J.,Meyer E.,Rudolph J.,Davisson V.J.,Stubbe J.
N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli.
Biochemistry
33
2269-2278
1994
977465
Thoden J.B.,Kappock T.J.,Stubbe J.,Holden H.M.
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.
Biochemistry
38
15480-15492
1999
977466
Thoden J.B.,Holden H.M.,Firestine S.M.
Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
Biochemistry
47
13346-13353
2008
