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Sequence of PTN1_HUMAN

EC Number:3.1.3.48

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
protein-tyrosine-phosphatase
P18031
Homo sapiens
435
49967
Reaction
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Other sequences found for EC No. 3.1.3.48

General information:

Sequence
show sequence in normal format
>P18031|protein-tyrosine-phosphatase|EC 3.1.3.48|Homo sapiens|Swiss-Prot
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
976927
Chernoff J.,Schievella A.R.,Jost C.A.,Erikson R.L.,Neel B.G.
Cloning of a cDNA for a major human protein-tyrosine-phosphatase.
Proc. Natl. Acad. Sci. U.S.A.
87
2735-2739
1990
976928
Brown-Shimer S.,Johnson K.A.,Lawrence J.B.,Johnson C.,Bruskin A.,Green N.R.,Hill D.E.
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.
Proc. Natl. Acad. Sci. U.S.A.
87
5148-5152
1990
976930
Deloukas P.,Matthews L.H.,Ashurst J.L.,Burton J.,Gilbert J.G.R.,Jones M.,Stavrides G.,Almeida J.P.,Babbage A.K.,Bagguley C.L.,Bailey J.,Barlow K.F.,Bates K.N.,Beard L.M.,Beare D.M.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Brown A.J.,Buck D.,Burrill W.D.,Butler A.P.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.,Clark G.,Clark L.N.,Clark S.Y.,Clee C.M.,Clegg S.,Cobley V.E.,Collier R.E.,Connor R.E.,Corby N.R.,Coulson A.,Coville G.J.,Deadman R.,Dhami P.D.,Dunn M.,Ellington A.G.,Frankland J.A.,Fraser A.,French L.,Garner P.,Grafham D.V.,Griffiths C.,Griffiths M.N.D.,Gwilliam R.,Hall R.E.,Hammond S.,Harley J.L.,Heath P.D.,Ho S.,Holden J.L.,Howden P.J.,Huckle E.,Hunt A.R.,Hunt S.E.,Jekosch K.,Johnson C.M.,Johnson D.,Kay M.P.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Lawlor S.,Lehvaeslaiho M.H.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Lovell J.D.,Marsh V.L.,Martin S.L.,McConnachie L.J.,McLay K.,McMurray A.A.,Milne S.A.,Mistry D.,Moore M.J.F.,Mullikin J.C.,Nickerson T.,Oliver K.,Parker A.,Patel R.,Pearce T.A.V.,Peck A.I.,Phillimore B.J.C.T.,Prathalingam S.R.,Plumb R.W.,Ramsay H.,Rice C.M.,Ross M.T.,Scott C.E.,Sehra H.K.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.L.,Soderlund C.,Steward C.A.,Sulston J.E.,Swann R.M.,Sycamore N.,Taylor R.,Tee L.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.C.,Vaudin M.,Wall M.,Wallis J.M.,Whitehead S.L.,Whittaker P.,Willey D.L.,Williams L.,Williams S.A.,Wilming L.,Wray P.W.,Hubbard T.,Durbin R.M.,Bentley D.R.,Beck S.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 20.
Nature
414
865-871
2001
976931
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
976932
Charbonneau H.,Tonks N.K.,Kumar S.,Diltz C.D.,Harrylock M.,Cool D.E.,Krebs E.G.,Fischer E.H.,Walsh K.A.
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
Proc. Natl. Acad. Sci. U.S.A.
86
5252-5256
1989
976933
Flint A.J.,Gebbink M.F.G.B.,Franza B.R. Jr.,Hill D.E.,Tonks N.K.
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.
EMBO J.
12
1937-1946
1993
976934
Frangioni J.V.,Beahm P.H.,Shifrin V.,Jost C.A.,Neel B.G.
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.
Cell
68
545-560
1992
976935
Liu F.,Chernoff J.
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.
Biochem. J.
327
139-145
1997
976936
Moeslein F.M.,Myers M.P.,Landreth G.E.
The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.
J. Biol. Chem.
274
26697-26704
1999
976937
Ravichandran L.V.,Chen H.,Li Y.,Quon M.J.
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
Mol. Endocrinol.
15
1768-1780
2001
976938
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
976939
Sangwan V.,Paliouras G.N.,Abella J.V.,Dube N.,Monast A.,Tremblay M.L.,Park M.
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.
J. Biol. Chem.
283
34374-34383
2008
976940
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
976941
Nievergall E.,Janes P.W.,Stegmayer C.,Vail M.E.,Haj F.G.,Teng S.W.,Neel B.G.,Bastiaens P.I.,Lackmann M.
PTP1B regulates Eph receptor function and trafficking.
J. Cell Biol.
191
1189-1203
2010
976942
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
976943
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
976944
Krishnan N.,Fu C.,Pappin D.J.,Tonks N.K.
H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.
Sci. Signal.
4
0-0
2011
976945
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
976946
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
976947
Mishra A.,Oules B.,Pisco A.O.,Ly T.,Liakath-Ali K.,Walko G.,Viswanathan P.,Tihy M.,Nijjher J.,Dunn S.J.,Lamond A.I.,Watt F.M.
A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.
Elife
6
0-0
2017
976948
Barford D.,Flint A.J.,Tonks N.K.
Crystal structure of human protein tyrosine phosphatase 1B.
Science
263
1397-1404
1994
976949
Puius Y.A.,Zhao Y.,Sullivan M.,Lawrence D.S.,Almo S.C.,Zhang Z.Y.
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc. Natl. Acad. Sci. U.S.A.
94
13420-13425
1997
976950
Pannifer A.D.,Flint A.J.,Tonks N.K.,Barford D.
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by X-ray crystallography.
J. Biol. Chem.
273
10454-10462
1998
976951
Groves M.R.,Yao Z.-J.,Roller P.P.,Burke T.R. Jr.,Barford D.
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry
37
17773-17783
1998
976952
Salmeen A.,Andersen J.N.,Myers M.P.,Meng T.-C.,Hinks J.A.,Tonks N.K.,Barford D.
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Nature
423
769-773
2003
976953
Van Montfort R.L.M.,Congreve M.,Tisi D.,Carr R.,Jhoti H.
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.
Nature
423
773-777
2003
976954
Ukkola O.,Rankinen T.,Lakka T.,Leon A.S.,Skinner J.S.,Wilmore J.H.,Rao D.C.,Kesaeniemi Y.A.,Bouchard C.
Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism.
Obes. Res.
13
829-834
2005