Sequence of AASS_ARATH

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
saccharopine dehydrogenase (NAD+, L-glutamate-forming)
Q9SMZ4
Arabidopsis thaliana
1064
117149
Reaction
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
Sequences with same EC No.
Sequence
show sequence in fasta format
   0 MNSNGHEEEK KLGNGVVGIL AETVNKWERR TPLTPSHCAR LLHGGKDRTG ISRIVVQPSA
  60 KRIHHDALYE DVGCEISDDL SDCGLILGIK QPELEMILPE RAYAFFSHTH KAQKENMPLL
 120 DKILSERVTL CDYELIVGDH GKRLLAFGKY AGRAGLVDFL HGLGQRKLIL GYSTPFLSLG
 180 ASYMYSSLAA AKAAVISVGE EIASQGLPLG ICPLVFVFTG TGNVSLGAQE IFKLLPHTFV
 240 EPSKLPELFV KDKGISQNGI STKRVYQVYG CIITSQDMVE HKDPSKSFDK ADYYAHPEHY
 300 NPVFHEKISP YTSVLVNCMY WEKRFPCLLS TKQLQDLTKK GLPLVGICDI TCDIGGSIEF
 360 VNRATLIDSP FFRFNPSNNS YYDDMDGDGV LCMAVDILPT EFAKEASQHF GDILSGFVGS
 420 LASMTEISDL PAHLKRACIS YRGELTSLYE YIPRMRKSNP EEAQDNIIAN GVSSQRTFNI
 480 LVSLSGHLFD KFLINEALDM IEAAGGSFHL AKCELGQSAD AESYSELEVG ADDKRVLDQI
 540 IDSLTRLANP NEDYISPHRE ANKISLKIGK VQQENEIKEK PEMTKKSGVL ILGAGRVCRP
 600 AADFLASVRT ISSQQWYKTY FGADSEEKTD VHVIVASLYL KDAKETVEGI SDVEAVRLDV
 660 SDSESLLKYV SQVDVVLSLL PASCHAVVAK TCIELKKHLV TASYVDDETS MLHEKAKSAG
 720 ITILGEMGLD PGIDHMMAMK MINDAHIKKG KVKSFTSYCG GLPSPAAANN PLAYKFSWNP
 780 AGAIRAGQNP AKYKSNGDII HVDGKNLYDS AARFRVPNLP AFALECFPNR DSLVYGEHYG
 840 IESEATTIFR GTLRYEGFSM IMATLSKLGF FDSEANQVLS TGKRITFGAL LSNILNKDAD
 900 NESEPLAGEE EISKRIIKLG HSKETAAKAA KTIVFLGFNE EREVPSLCKS VFDATCYLME
 960 EKLAYSGNEQ DMVLLHHEVE VEFLESKRIE KHTATLLEFG DIKNGQTTTA MAKTVGIPAA
1020 IGALLLIEDK IKTRGVLRPL EAEVYLPALD ILQAYGIKLM EKAE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
979036
Tang G.,Miron D.,Zhu-Shimoni J.X.,Galili G.
Regulation of lysine catabolism through lysine-ketoglutarate reductase and saccharopine dehydrogenase in Arabidopsis.
Plant Cell
9
1305-1316
1997
979037
Epelbaum S.,McDevitt R.,Falco S.C.
Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana: nucleotide sequence and characterization.
Plant Mol. Biol.
35
735-748
1997
979038
Tang G.,Zhu X.,Gakiere B.,Levanony H.,Kahana A.,Galili G.
The bifunctional LKR/SDH locus of plants also encodes a highly active monofunctional lysine-ketoglutarate reductase using a polyadenylation signal located within an intron.
Plant Physiol.
130
147-154
2002
979039
Mayer K.F.X.,Schueller C.,Wambutt R.,Murphy G.,Volckaert G.,Pohl T.,Duesterhoeft A.,Stiekema W.,Entian K.-D.,Terryn N.,Harris B.,Ansorge W.,Brandt P.,Grivell L.A.,Rieger M.,Weichselgartner M.,de Simone V.,Obermaier B.,Mache R.,Mueller M.,Kreis M.,Delseny M.,Puigdomenech P.,Watson M.,Schmidtheini T.,Reichert B.,Portetelle D.,Perez-Alonso M.,Boutry M.,Bancroft I.,Vos P.,Hoheisel J.,Zimmermann W.,Wedler H.,Ridley P.,Langham S.-A.,McCullagh B.,Bilham L.,Robben J.,van der Schueren J.,Grymonprez B.,Chuang Y.-J.,Vandenbussche F.,Braeken M.,Weltjens I.,Voet M.,Bastiaens I.,Aert R.,Defoor E.,Weitzenegger T.,Bothe G.,Ramsperger U.,Hilbert H.,Braun M.,Holzer E.,Brandt A.,Peters S.,van Staveren M.,Dirkse W.,Mooijman P.,Klein Lankhorst R.,Rose M.,Hauf J.,Koetter P.,Berneiser S.,Hempel S.,Feldpausch M.,Lamberth S.,Van den Daele H.,De Keyser A.,Buysshaert C.,Gielen J.,Villarroel R.,De Clercq R.,van Montagu M.,Rogers J.,Cronin A.,Quail M.A.,Bray-Allen S.,Clark L.,Doggett J.,Hall S.,Kay M.,Lennard N.,McLay K.,Mayes R.,Pettett A.,Rajandream M.A.,Lyne M.,Benes V.,Rechmann S.,Borkova D.,Bloecker H.,Scharfe M.,Grimm M.,Loehnert T.-H.,Dose S.,de Haan M.,Maarse A.C.,Schaefer M.,Mueller-Auer S.,Gabel C.,Fuchs M.,Fartmann B.,Granderath K.,Dauner D.,Herzl A.,Neumann S.,Argiriou A.,Vitale D.,Liguori R.,Piravandi E.,Massenet O.,Quigley F.,Clabauld G.,Muendlein A.,Felber R.,Schnabl S.,Hiller R.,Schmidt W.,Lecharny A.,Aubourg S.,Chefdor F.,Cooke R.,Berger C.,Monfort A.,Casacuberta E.,Gibbons T.,Weber N.,Vandenbol M.,Bargues M.,Terol J.,Torres A.,Perez-Perez A.,Purnelle B.,Bent E.,Johnson S.,Tacon D.,Jesse T.,Heijnen L.,Schwarz S.,Scholler P.,Heber S.,Francs P.,Bielke C.,Frishman D.,Haase D.,Lemcke K.,Mewes H.-W.,Stocker S.,Zaccaria P.,Bevan M.,Wilson R.K.,de la Bastide M.,Habermann K.,Parnell L.,Dedhia N.,Gnoj L.,Schutz K.,Huang E.,Spiegel L.,Sekhon M.,Murray J.,Sheet P.,Cordes M.,Abu-Threideh J.,Stoneking T.,Kalicki J.,Graves T.,Harmon G.,Edwards J.,Latreille P.,Courtney L.,Cloud J.,Abbott A.,Scott K.,Johnson D.,Minx P.,Bentley D.,Fulton B.,Miller N.,Greco T.,Kemp K.,Kramer J.,Fulton L.,Mardis E.,Dante M.,Pepin K.,Hillier L.W.,Nelson J.,Spieth J.,Ryan E.,Andrews S.,Geisel C.,Layman D.,Du H.,Ali J.,Berghoff A.,Jones K.,Drone K.,Cotton M.,Joshu C.,Antonoiu B.,Zidanic M.,Strong C.,Sun H.,Lamar B.,Yordan C.,Ma P.,Zhong J.,Preston R.,Vil D.,Shekher M.,Matero A.,Shah R.,Swaby I.K.,O'Shaughnessy A.,Rodriguez M.,Hoffman J.,Till S.,Granat S.,Shohdy N.,Hasegawa A.,Hameed A.,Lodhi M.,Johnson A.,Chen E.,Marra M.A.,Martienssen R.,McCombie W.R.
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
Nature
402
769-777
1999
979040
Cheng C.Y.,Krishnakumar V.,Chan A.P.,Thibaud-Nissen F.,Schobel S.,Town C.D.
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
Plant J.
89
789-804
2017
979041
Yamada K.,Lim J.,Dale J.M.,Chen H.,Shinn P.,Palm C.J.,Southwick A.M.,Wu H.C.,Kim C.J.,Nguyen M.,Pham P.K.,Cheuk R.F.,Karlin-Newmann G.,Liu S.X.,Lam B.,Sakano H.,Wu T.,Yu G.,Miranda M.,Quach H.L.,Tripp M.,Chang C.H.,Lee J.M.,Toriumi M.J.,Chan M.M.,Tang C.C.,Onodera C.S.,Deng J.M.,Akiyama K.,Ansari Y.,Arakawa T.,Banh J.,Banno F.,Bowser L.,Brooks S.Y.,Carninci P.,Chao Q.,Choy N.,Enju A.,Goldsmith A.D.,Gurjal M.,Hansen N.F.,Hayashizaki Y.,Johnson-Hopson C.,Hsuan V.W.,Iida K.,Karnes M.,Khan S.,Koesema E.,Ishida J.,Jiang P.X.,Jones T.,Kawai J.,Kamiya A.,Meyers C.,Nakajima M.,Narusaka M.,Seki M.,Sakurai T.,Satou M.,Tamse R.,Vaysberg M.,Wallender E.K.,Wong C.,Yamamura Y.,Yuan S.,Shinozaki K.,Davis R.W.,Theologis A.,Ecker J.R.
Empirical analysis of transcriptional activity in the Arabidopsis genome.
Science
302
842-846
2003
979042
Tang G.,Zhu X.,Tang X.,Galili G.
A novel composite locus of Arabidopsis encoding two polypeptides with metabolically related but distinct functions in lysine catabolism.
Plant J.
23
195-203
2000
979043
Zhu X.,Tang G.,Galili G.
Characterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite AtLKR/SDH locus of Arabidopsis.
Plant Physiol.
124
1363-1371
2000
979044
Zhu X.,Tang G.,Granier F.,Bouchez D.,Galili G.
A T-DNA insertion knockout of the bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase gene elevates lysine levels in Arabidopsis seeds.
Plant Physiol.
126
1539-1545
2001
979045
Zhu X.,Tang G.,Galili G.
The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains.
J. Biol. Chem.
277
49655-49661
2002
979046
Stepansky A.,Galili G.
Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals.
Plant Physiol.
133
1407-1415
2003
979047
Stepansky A.,Yao Y.,Tang G.,Galili G.
Regulation of lysine catabolism in Arabidopsis through concertedly regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus.
J. Exp. Bot.
56
525-536
2005