Sequence of PKNA_MYCTU
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P9WI83
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
431
45597
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSPRVGVTLS GRYRLQRLIA TGGMGQVWEA VDNRLGRRVA VKVLKSEFSS DPEFIERFRA
60 EARTTAMLNH PGIASVHDYG ESQMNGEGRT AYLVMELVNG EPLNSVLKRT GRLSLRHALD
120 MLEQTGRALQ IAHAAGLVHR DVKPGNILIT PTGQVKITDF GIAKAVDAAP VTQTGMVMGT
180 AQYIAPEQAL GHDASPASDV YSLGVVGYEA VSGKRPFAGD GALTVAMKHI KEPPPPLPPD
240 LPPNVRELIE ITLVKNPAMR YRSGGPFADA VAAVRAGRRP PRPSQTPPPG RAAPAAIPSG
300 TTARVAANSA GRTAASRRSR PATGGHRPPR RTFSSGQRAL LWAAGVLGAL AIIIAVLLVI
360 KAPGDNSPQQ APTPTVTTTG NPPASNTGGT DASPRLNWTE RGETRHSGLQ SWVVPPTPHS
420 RASLARYEIA Q
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
971628
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
971629
Kang C.M.,Abbott D.W.,Park S.T.,Dascher C.C.,Cantley L.C.,Husson R.N.
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
Genes Dev.
19
1692-1704
2005
971630
Sharma K.,Gupta M.,Krupa A.,Srinivasan N.,Singh Y.
EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis.
FEBS J.
273
2711-2721
2006
971631
Molle V.,Zanella-Cleon I.,Robin J.P.,Mallejac S.,Cozzone A.J.,Becchi M.
Characterization of the phosphorylation sites of Mycobacterium tuberculosis serine/threonine protein kinases, PknA, PknD, PknE, and PknH by mass spectrometry.
Proteomics
6
3754-3766
2006
971632
Parikh A.,Verma S.K.,Khan S.,Prakash B.,Nandicoori V.K.
PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity.
J. Mol. Biol.
386
451-464
2009
971633
Jani C.,Eoh H.,Lee J.J.,Hamasha K.,Sahana M.B.,Han J.S.,Nyayapathy S.,Lee J.Y.,Suh J.W.,Lee S.H.,Rehse S.J.,Crick D.C.,Kang C.M.
Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria.
BMC Microbiol.
10
327-327
2010
971634
Sureka K.,Hossain T.,Mukherjee P.,Chatterjee P.,Datta P.,Kundu M.,Basu J.
Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division.
PLoS ONE
5
0-0
2010
971636
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
971637
Sajid A.,Arora G.,Gupta M.,Upadhyay S.,Nandicoori V.K.,Singh Y.
Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.
PLoS ONE
6
0-0
2011
971638
Mir M.,Asong J.,Li X.,Cardot J.,Boons G.J.,Husson R.N.
The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.
PLoS Pathog.
7
0-0
2011
971639
Anandan T.,Han J.,Baun H.,Nyayapathy S.,Brown J.T.,Dial R.L.,Moltalvo J.A.,Kim M.S.,Yang S.H.,Ronning D.R.,Husson R.N.,Suh J.,Kang C.M.
Phosphorylation regulates mycobacterial proteasome.
J. Microbiol.
52
743-754
2014
971640
Nagarajan S.N.,Upadhyay S.,Chawla Y.,Khan S.,Naz S.,Subramanian J.,Gandotra S.,Nandicoori V.K.
Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.
J. Biol. Chem.
290
9626-9645
2015
971641
Ravala S.K.,Singh S.,Yadav G.S.,Kumar S.,Karthikeyan S.,Chakraborti P.K.
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.
FEBS J.
282
1419-1431
2015
971642
Wagner T.,Alexandre M.,Duran R.,Barilone N.,Wehenkel A.,Alzari P.M.,Bellinzoni M.
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Proteins
83
982-988
2015
