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Sequence of CDK2_HUMAN

EC Number:2.7.11.22

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cyclin-dependent kinase
P24941
Homo sapiens
298
33930
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.22

General information:

Sequence
show sequence in fasta format
  0 MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH
 60 PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS
120 HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY
180 STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF
240 PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
908653
Elledge S.J.,Spottswood M.R.
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
EMBO J.
10
2653-2659
1991
908654
Tsai L.-H.,Harlow E.,Meyerson M.
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
Nature
353
174-177
1991
908655
Ninomiya-Tsuji J.,Nomoto S.,Yasuda H.,Reed S.I.,Matsumoto K.
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.
Proc. Natl. Acad. Sci. U.S.A.
88
9006-9010
1991
908659
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
908660
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
908662
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
908663
Gu Y.,Rosenblatt J.,O'Morgan D.O.
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
EMBO J.
11
3995-4005
1992
908664
Meijer L.,Borgne A.,Mulner O.,Chong J.P.J.,Blow J.J.,Inagaki N.,Inagaki M.,Delcros J.-G.,Moulinoux J.-P.
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Eur. J. Biochem.
243
527-536
1997
908665
Harbour J.W.,Luo R.X.,Dei Santi A.,Postigo A.A.,Dean D.C.
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.
Cell
98
859-869
1999
908666
Okuda M.,Horn H.F.,Tarapore P.,Tokuyama Y.,Smulian A.G.,Chan P.K.,Knudsen E.S.,Hofmann I.A.,Snyder J.D.,Bove K.E.,Fukasawa K.
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Cell
103
127-140
2000
908667
Zhao J.,Kennedy B.K.,Lawrence B.D.,Barbie D.A.,Matera A.G.,Fletcher J.A.,Harlow E.
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
Genes Dev.
14
2283-2297
2000
908668
Ma T.,Van Tine B.A.,Wei Y.,Garrett M.D.,Nelson D.,Adams P.D.,Wang J.,Qin J.,Chow L.T.,Harper J.W.
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
Genes Dev.
14
2298-2313
2000
908669
Luciani M.G.,Hutchins J.R.A.,Zheleva D.,Hupp T.R.
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
J. Mol. Biol.
300
503-518
2000
908670
Garrett S.,Barton W.A.,Knights R.,Jin P.,Morgan D.O.,Fisher R.P.
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Mol. Cell. Biol.
21
88-99
2001
908671
Nguyen T.B.,Manova K.,Capodieci P.,Lindon C.,Bottega S.,Wang X.-Y.,Refik-Rogers J.,Pines J.,Wolgemuth D.J.,Koff A.
Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
J. Biol. Chem.
277
41960-41969
2002
908672
Porter L.A.,Dellinger R.W.,Tynan J.A.,Barnes E.A.,Kong M.,Lenormand J.-L.,Donoghue D.J.
Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.
J. Cell Biol.
157
357-366
2002
908673
Barnes E.A.,Porter L.A.,Lenormand J.-L.,Dellinger R.W.,Donoghue D.J.
Human Spy1 promotes survival of mammalian cells following DNA damage.
Cancer Res.
63
3701-3707
2003
908674
Terret M.E.,Lefebvre C.,Djiane A.,Rassinier P.,Moreau J.,Maro B.,Verlhac M.H.
DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
Development
130
5169-5177
2003
908675
Porter L.A.,Kong-Beltran M.,Donoghue D.J.
Spy1 interacts with p27Kip1 to allow G1/S progression.
Mol. Biol. Cell
14
3664-3674
2003
908676
Li Y.,Mori T.,Hata H.,Homma Y.,Kochi H.
NIRF induces G1 arrest and associates with Cdk2.
Biochem. Biophys. Res. Commun.
319
464-468
2004
908677
Wang G.L.,Iakova P.,Wilde M.,Awad S.,Timchenko N.A.
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
Genes Dev.
18
912-925
2004
908678
Liu Y.,Wu C.,Galaktionov K.
p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
J. Biol. Chem.
279
4507-4514
2004
908679
Cheng A.,Xiong W.,Ferrell J.E. Jr.,Solomon M.J.
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.
Cell Cycle
4
155-165
2005
908680
Esashi F.,Christ N.,Gannon J.,Liu Y.,Hunt T.,Jasin M.,West S.C.
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
Nature
434
598-604
2005
908681
Lolli G.,Johnson L.N.
Recognition of Cdk2 by Cdk7.
Proteins
67
1048-1059
2007
908682
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
908683
De Boer L.,Oakes V.,Beamish H.,Giles N.,Stevens F.,Somodevilla-Torres M.,Desouza C.,Gabrielli B.
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
Oncogene
27
4261-4268
2008
908684
Kong Y.,Nan K.,Yin Y.
Identification and characterization of CAC1 as a novel CDK2-associated cullin.
Cell Cycle
8
3552-3561
2009
908685
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
908686
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
908687
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
908688
Flores O.,Wang Z.,Knudsen K.E.,Burnstein K.L.
Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.
Endocrinology
151
896-908
2010
908689
Kumar S.,Barthwal M.K.,Dikshit M.
Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.
Free Radic. Biol. Med.
48
851-861
2010
908690
Timofeev O.,Cizmecioglu O.,Settele F.,Kempf T.,Hoffmann I.
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
J. Biol. Chem.
285
16978-16990
2010
908691
Chen S.,Bohrer L.R.,Rai A.N.,Pan Y.,Gan L.,Zhou X.,Bagchi A.,Simon J.A.,Huang H.
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
Nat. Cell Biol.
12
1108-1114
2010
908692
Chung J.H.,Bunz F.
Cdk2 is required for p53-independent G2/M checkpoint control.
PLoS Genet.
6
0-0
2010
908693
Hydbring P.,Bahram F.,Su Y.,Tronnersjoe S.,Hoegstrand K.,von der Lehr N.,Sharifi H.R.,Lilischkis R.,Hein N.,Wu S.,Vervoorts J.,Henriksson M.,Grandien A.,Luescher B.,Larsson L.-G.
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
Proc. Natl. Acad. Sci. U.S.A.
107
58-63
2010
908694
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
908695
Loffler H.,Fechter A.,Matuszewska M.,Saffrich R.,Mistrik M.,Marhold J.,Hornung C.,Westermann F.,Bartek J.,Kramer A.
Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Cancer Res.
71
2129-2139
2011
908696
Fiset A.,Xu E.,Bergeron S.,Marette A.,Pelletier G.,Siminovitch K.A.,Olivier M.,Beauchemin N.,Faure R.L.
Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.
Cell. Signal.
23
911-919
2011
908697
Lee J.,Kim K.H.,Jeong S.
Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
Bioorg. Med. Chem. Lett.
21
4203-4205
2011
908698
Huang X.,Summers M.K.,Pham V.,Lill J.R.,Liu J.,Lee G.,Kirkpatrick D.S.,Jackson P.K.,Fang G.,Dixit V.M.
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Mol. Cell
42
511-523
2011
908699
Neganova I.,Vilella F.,Atkinson S.P.,Lloret M.,Passos J.F.,von Zglinicki T.,O'Connor J.-E.,Burks D.,Jones R.,Armstrong L.,Lako M.
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
Stem Cells
29
651-659
2011
908700
Satyanarayana A.,Kaldis P.
A dual role of Cdk2 in DNA damage response.
Cell Div.
4
9-9
2009
908701
Malumbres M.,Barbacid M.
Cell cycle, CDKs and cancer: a changing paradigm.
Nat. Rev. Cancer
9
153-166
2009
908702
Satyanarayana A.,Kaldis P.
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.
Oncogene
28
2925-2939
2009
908703
Hydbring P.,Larsson L.-G.
Tipping the balance: Cdk2 enables Myc to suppress senescence.
Cancer Res.
70
6687-6691
2010
908704
Wang Q.,Su L.,Liu N.,Zhang L.,Xu W.,Fang H.
Cyclin dependent kinase 1 inhibitors: a review of recent progress.
Curr. Med. Chem.
18
2025-2043
2011
908705
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
908706
Liu Q.,Liu X.,Gao J.,Shi X.,Hu X.,Wang S.,Luo Y.
Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.
Int. J. Biol. Sci.
9
541-549
2013
908707
Batenburg N.L.,Walker J.R.,Noordermeer S.M.,Moatti N.,Durocher D.,Zhu X.D.
ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.
Nat. Commun.
8
1921-1921
2017
908708
de Bondt H.L.,Rosenblatt J.,Jancarik J.,Jones H.D.,Morgan D.O.,Kim S.-H.
Crystal structure of cyclin-dependent kinase 2.
Nature
363
595-602
1993
908709
Jeffrey P.D.,Russo A.A.,Polyak K.,Gibbs E.,Hurwitz J.,Massague J.,Pavletich N.P.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature
376
313-320
1995
908710
Bourne Y.,Watson M.H.,Hickey M.J.,Holmes W.,Rocque W.,Reed S.I.,Tainer J.A.
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell
84
863-874
1996
908711
Schulze-Gahmen U.,de Bondt H.L.,Kim S.-H.
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
J. Med. Chem.
39
4540-4546
1996
908712
Russo A.A.,Jeffrey P.D.,Patten A.K.,Massague J.,Pavletich N.P.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature
382
325-331
1996
908713
Russo A.A.,Jeffrey P.D.,Pavletich N.P.
Structural basis of cyclin-dependent kinase activation by phosphorylation.
Nat. Struct. Biol.
3
696-700
1996
908714
de Azevedo W.F. Jr.,Mueller-Dieckmann H.-J.,Schulze-Gahmen U.,Worland P.J.,Sausville E.,Kim S.-H.
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
Proc. Natl. Acad. Sci. U.S.A.
93
2735-2740
1996
908715
Lawrie A.M.,Noble M.E.M.,Tunnah P.,Brown N.R.,Johnson L.N.,Endicott J.A.
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat. Struct. Biol.
4
796-801
1997
908716
Gray N.S.,Wodicka L.,Thunnissen A.-M.W.H.,Norman T.C.,Kwon S.,Espinoza F.H.,Morgan D.O.,Barnes G.,Leclerc S.,Meijer L.,Kim S.H.,Lockhart D.J.,Schultz P.G.
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science
281
533-538
1998
908717
Richardson C.M.,Williamson D.S.,Parratt M.J.,Borgognoni J.,Cansfield A.D.,Dokurno P.,Francis G.L.,Howes R.,Moore J.D.,Murray J.B.,Robertson A.,Surgenor A.E.,Torrance C.J.
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorg. Med. Chem. Lett.
16
1353-1357
2006
908718
Richardson C.M.,Nunns C.L.,Williamson D.S.,Parratt M.J.,Dokurno P.,Howes R.,Borgognoni J.,Drysdale M.J.,Finch H.,Hubbard R.E.,Jackson P.S.,Kierstan P.,Lentzen G.,Moore J.D.,Murray J.B.,Simmonite H.,Surgenor A.E.,Torrance C.J.
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Bioorg. Med. Chem. Lett.
17
3880-3885
2007
908719
Brown N.R.,Lowe E.D.,Petri E.,Skamnaki V.,Antrobus R.,Johnson L.N.
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell Cycle
6
1350-1359
2007
908720
Welburn J.P.I.,Tucker J.A.,Johnson T.,Lindert L.,Morgan M.,Willis A.,Noble M.E.M.,Endicott J.A.
How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.
J. Biol. Chem.
282
3173-3181
2007
908721
Fischmann T.O.,Hruza A.,Duca J.S.,Ramanathan L.,Mayhood T.,Windsor W.T.,Le H.V.,Guzi T.J.,Dwyer M.P.,Paruch K.,Doll R.J.,Lees E.,Parry D.,Seghezzi W.,Madison V.
Structure-guided discovery of cyclin-dependent kinase inhibitors.
Biopolymers
89
372-379
2008
908722
Wyatt P.G.,Woodhead A.J.,Berdini V.,Boulstridge J.A.,Carr M.G.,Cross D.M.,Davis D.J.,Devine L.A.,Early T.R.,Feltell R.E.,Lewis E.J.,McMenamin R.L.,Navarro E.F.,O'Brien M.A.,O'Reilly M.,Reule M.,Saxty G.,Seavers L.C.,Smith D.M.,Squires M.S.,Trewartha G.,Walker M.T.,Woolford A.J.
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
J. Med. Chem.
51
4986-4999
2008
908723
Bao Z.Q.,Jacobsen D.M.,Young M.A.
Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
Structure
19
675-690
2011
908724
McGrath D.A.,Fifield B.A.,Marceau A.H.,Tripathi S.,Porter L.A.,Rubin S.M.
Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
EMBO J.
36
2251-2262
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