Sequence of PTEN_CAEEL
EC Number:3.1.3.67
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
G5EE01
Caenorhabditis elegans
962
110329
Reaction
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate
Other sequences found for EC No. 3.1.3.67
General information:
Sequence
0 MVTPPPDVPS TSTRSMARDL QENPNRQPGE PRVSEPYHNS IVERIRHIFR TAVSSNRCRT
60 EYQNIDLDCA YITDRIIAIG YPATGIEANF RNSKVQTQQF LTRRHGKGNV KVFNLRGGYY
120 YDADNFDGNV ICFDMTDHHP PSLELMAPFC REAKEWLEAD DKHVIAVHCK AGKGRTGVMI
180 CALLIYINFY PSPRQILDYY SIIRTKNNKG VTIPSQRRYI YYYHKLRERE LNYLPLRMQL
240 IGVYVERPPK TWGGGSKIKV EVGNGSTILF KPDPLIISKS NHQRERATWL NNCDTPNEFD
300 TGEQKYHGFV SKRAYCFMVP EDAPVFVEGD VRIDIREIGF LKKFSDGKIG HVWFNTMFAC
360 DGGLNGGHFE YVDKTQPYIG DDTSIGRKNG MRRNETPMRK IDPETGNEFE SPWQIVNPPG
420 LEKHITEEQA MENYTNYGMI PPRYTISKIL HEKHEKGIVK DDYNDRKLPM GDKSYTESGK
480 SGDIRGVGGP FEIPYKAEEH VLTFPVYEMD RALKSKDLNN GMKLHVVLRC VDTRDSKMME
540 KSEVFGNLAF HNESTRRLQA LTQMNPKWRP EPCAFGSKGA EMHYPPSVRY SSNDGKYNGA
600 CSENLVSDFF EHRNIAVLNR YCRYFYKQRS TSRSRYPRKF RYCPLIKKHF YIPADTDDVD
660 ENGQPFFHSP EHYIKEQEKI DAEKAAKGIE NTGPSTSGSS APGTIKKTEA SQSDKVKPAT
720 EDELPPARLP DNVRRFPVVG VDFENPEEES CEHKTVESIA GFEPLEHLFH ESYHPNTAGN
780 MLRQDYHTDS EVKIAEQEAK AFVDQLLNGQ GVLQEFMKQF KVPSDNSFAD YVTGQAEVFK
840 AQIALLEQSE DFQRVQANAE EVDLEHTLGE AFERFGHVVE ESNGSSKNPK ALKTREQMVK
900 ETGKDTQKTR NHVLLHLEAN HRVQIERRET CPELHPEDKI PRIAHFSENS FSDSNFDQAI
960 YL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
80237
Ogg S.,Ruvkun G.
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
Mol. Cell
2
887-893
1998
80238
Rouault J.P.,Kuwabara P.E.,Sinilnikova O.M.,Duret L.,Thierry-Mieg D.,Billaud M.
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN.
Curr. Biol.
9
329-332
1999
80239
Gil E.B.,Malone Link E.,Liu L.X.,Johnson C.D.,Lees J.A.
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
Proc. Natl. Acad. Sci. U.S.A.
96
2925-2930
1999
80240
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
80241
Mihaylova V.T.,Borland C.Z.,Manjarrez L.,Stern M.J.,Sun H.
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway.
Proc. Natl. Acad. Sci. U.S.A.
96
7427-7432
1999
80242
Solari F.,Bourbon-Piffaut A.,Masse I.,Payrastre B.,Chan A.M.,Billaud M.
The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.
Oncogene
24
20-27
2005
80243
Fukuyama M.,Rougvie A.E.,Rothman J.H.
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.
Curr. Biol.
16
773-779
2006
80244
Suzuki Y.,Han M.
Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.
Genes Dev.
20
423-428
2006
80245
Tomioka M.,Adachi T.,Suzuki H.,Kunitomo H.,Schafer W.R.,Iino Y.
The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.
Neuron
51
613-625
2006
80246
Dixon S.J.,Alexander M.,Chan K.K.,Roy P.J.
Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.
Dev. Biol.
318
153-161
2008
80247
Brisbin S.,Liu J.,Boudreau J.,Peng J.,Evangelista M.,Chin-Sang I.
A role for C. elegans Eph RTK signaling in PTEN regulation.
Dev. Cell
17
459-469
2009
80248
Padmanabhan S.,Mukhopadhyay A.,Narasimhan S.D.,Tesz G.,Czech M.P.,Tissenbaum H.A.
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Cell
136
939-951
2009
80249
Palmitessa A.,Benovic J.L.
Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
J. Biol. Chem.
285
15187-15200
2010
80250
Christensen R.,de la Torre-Ubieta L.,Bonni A.,Colon-Ramos D.A.
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development.
Development
138
5257-5267
2011
80251
Nakdimon I.,Walser M.,Froehli E.,Hajnal A.
PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.
PLoS Genet.
8
0-0
2012
80252
Nakagawa A.,Sullivan K.D.,Xue D.
Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.
Nat. Struct. Mol. Biol.
21
1082-1090
2014
80253
Liu J.,Visser-Grieve S.,Boudreau J.,Yeung B.,Lo S.,Chamberlain G.,Yu F.,Sun T.,Papanicolaou T.,Lam A.,Yang X.,Chin-Sang I.
Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.
Oncogene
33
3878-3885
2014
80254
Narbonne P.,Maddox P.S.,Labbe J.C.
DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.
Development
142
4230-4241
2015
