Sequence of VM2AE_CROAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
atrolysin E
P34182
Crotalus atrox
478
53638
Reaction
Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV)
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MIQVLLVTIC LAAFPYQGSS IILESGNVND YEVIYPRKVT ALPKGAVQPK YEDTMQYELK
 60 VNGEPVVLHL EKNKGLFSKD YSETHYSFDG RKITTNPSVE DHCYYHGRIE NDADSTASIS
120 ACNGLKGHFK LQGEMYLIEP LKLSDSEAHA VFKLKNVEKE DEAPKMCGVT QNWESYEPIK
180 KASDLNLNPE HQRYVELFIV VDHGMYTKYN GDSDKIRQRV HQMVNIMKES YTYMYIDILL
240 AGIEIWSNGD LINVQPASPN TLNSFGEWRE TDLLKRKSHD NAQLLTSIAF DEQIIGRAYI
300 GGICDPKRST GVVQDHSEIN LRVAVTMTHE LGHNLGIHHD TDSCSCGGYS CIMSPVISDE
360 PSKYFSDCSY IQCWEFIMNQ KPQCILKKPL RTDTVSTPVS GNELLEAGIE CDCGSLENPC
420 CYATTCKMRP GSQCAEGLCC DQCRFMKKGT VCRVSMVDRN DDTCTGQSAD CPRNGLYG
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
846490
Hite L.A.,Shannon J.D.,Bjarnason J.B.,Fox J.W.
Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin e from Crotalus atrox: evidence for signal, zymogen, and disintegrin-like structures.
Biochemistry
31
6203-6211
1992
846491
Hite L.A.,Fox J.W.,Bjarnason J.B.
A new family of proteinases is defined by several snake venom metalloproteinases.
Biol. Chem. Hoppe-Seyler
373
381-385
1992
846492
Shimokawa K.,Jia L.G.,Shannon J.D.,Fox J.W.
Isolation, sequence analysis, and biological activity of atrolysin E/D, the non-RGD disintegrin domain from Crotalus atrox venom.
Arch. Biochem. Biophys.
354
239-246
1998
846493
Calvete J.J.,Fasoli E.,Sanz L.,Boschetti E.,Righetti P.G.
Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches.
J. Proteome Res.
8
3055-3067
2009
846494
Baramova E.N.,Shannon J.D.,Bjarnason J.B.,Fox J.W.
Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases.
Arch. Biochem. Biophys.
275
63-71
1989
846495
Shimokawa K.,Jia L.G.,Wang X.M.,Fox J.W.
Expression, activation, and processing of the recombinant snake venom metalloproteinase, pro-atrolysin E.
Arch. Biochem. Biophys.
335
283-294
1996