Sequence of PIKC_STRVZ
EC Number:1.14.15.33
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Other sequences found for EC No. 1.14.15.33
General information:
Sequence
0 MRRTQQGTTA SPPVLDLGAL GQDFAADPYP TYARLRAEGP AHRVRTPEGD EVWLVVGYDR
60 ARAVLADPRF SKDWRNSTTP LTEAEAALNH NMLESDPPRH TRLRKLVARE FTMRRVELLR
120 PRVQEIVDGL VDAMLAAPDG RADLMESLAW PLPITVISEL LGVPEPDRAA FRVWTDAFVF
180 PDDPAQAQTA MAEMSGYLSR LIDSKRGQDG EDLLSALVRT SDEDGSRLTS EELLGMAHIL
240 LVAGHETTVN LIANGMYALL SHPDQLAALR ADMTLLDGAV EEMLRYEGPV ESATYRFPVE
300 PVDLDGTVIP AGDTVLVVLA DAHRTPERFP DPHRFDIRRD TAGHLAFGHG IHFCIGAPLA
360 RLEARIAVRA LLERCPDLAL DVSPGELVWY PNPMIRGLKA LPIRWRRGRE AGRRTG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
840735
Betlach M.C.,Kealey J.T.,Ashley G.W.,McDaniel R.
Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin.
Biochemistry
37
14937-14942
1998
840736
Xue Y.,Wilson D.,Zhao L.,Liu H.,Sherman D.H.
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.
Chem. Biol.
5
661-667
1998
840737
Xue Y.,Zhao L.,Liu H.W.,Sherman D.H.
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
Proc. Natl. Acad. Sci. U.S.A.
95
12111-12116
1998
840738
Sherman D.H.,Li S.,Yermalitskaya L.V.,Kim Y.,Smith J.A.,Waterman M.R.,Podust L.M.
The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.
J. Biol. Chem.
281
26289-26297
2006
840739
Li S.,Ouellet H.,Sherman D.H.,Podust L.M.
Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.
J. Biol. Chem.
284
5723-5730
2009
840740
Li S.,Chaulagain M.R.,Knauff A.R.,Podust L.M.,Montgomery J.,Sherman D.H.
Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase.
Proc. Natl. Acad. Sci. U.S.A.
106
18463-18468
2009
840741
Negretti S.,Narayan A.R.,Chiou K.C.,Kells P.M.,Stachowski J.L.,Hansen D.A.,Podust L.M.,Montgomery J.,Sherman D.H.
Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation.
J. Am. Chem. Soc.
136
4901-4904
2014
