Sequence of NEP_RAT
EC Number:3.4.24.11
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Other sequences found for EC No. 3.4.24.11
General information:
Sequence
0 MGRSESQMDI TDINAPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS
60 DCIKSAARLI QNMDASAEPC TDFFKYACGG WLKRNVIPET SSRYSNFDIL RDELEVILKD
120 VLQEPKTEDI VAVQKAKTLY RSCINESAID SRGGQPLLTL LPDIYGWPVA SQNWEQTYGT
180 SWTAEKSIAQ LNSKYGKKVL INFFVGTDDK NSTQHIIHFD QPRLGLPSRD YYECTGIYKE
240 ACTAYVDFMI SVARLIRQEQ RLPIDENQLS LEMNKVMELE KEIANATTKP EDRNDPMLLY
300 NKMTLAKLQN NFSLEINGKP FSWSNFTNEI MSTVNINIQN EEEVVVYAPE YLTKLKPILT
360 KYSPRDLQNL MSWRFIMDLV SSLSRNYKES RNAFRKALYG TTSETATWRR CANYVNGNME
420 NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKKAE EKALAIKERI
480 GYPDDIISNE NKLNNEYLEL NYKEEEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA
540 VVNAFYSSGR NQIVFPAGIL QPPFFSARQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD
600 GDLVDWWTQQ SANNFKDQSQ CMVYQYGNFT WDLAGGQHLN GINTLGENIA DNGGIGQAYR
660 AYQNYVKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII
720 GTLQNSAEFA DAFHCRKNSY MNPERKCRVW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
831207
Malfroy B.,Schofield P.R.,Kuang W.-J.,Seeburg P.H.,Mason A.J.,Henzel W.J.
Molecular cloning and amino acid sequence of rat enkephalinase.
Biochem. Biophys. Res. Commun.
144
59-66
1987
831208
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
831209
Sonnenberg J.L.,Sakane Y.,Jeng A.Y.,Koehn J.A.,Ansell J.A.,Wennogle L.P.,Ghai R.D.
Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.
Peptides
9
173-180
1988
831210
Bateman R.C. Jr.,Jackson D.,Slaughter C.A.,Unnithan S.,Chai Y.G.,Moomaw C.,Hersh L.B.
Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.
J. Biol. Chem.
264
6151-6157
1989
831211
Rougeot C.,Messaoudi M.,Hermitte V.,Rigault A.G.,Blisnick T.,Dugave C.,Desor D.,Rougeon F.
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Proc. Natl. Acad. Sci. U.S.A.
100
8549-8554
2003
831212
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
