Sequence of LOVD_ASPTN
EC Number:2.3.1.238
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
monacolin J acid methylbutanoate transferase
Q0C8M0
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
413
46056
Reaction
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase]
Other sequences found for EC No. 2.3.1.238
General information:
Sequence
0 MGSIIDAAAA ADPVVLMETA FRKAVKSRQI PGAVIMARDC SGNLNYTRCF GARTVRRDEC
60 NQLPPLQVDT PCRLASATKL LTTIMALQCM ERGLVDLDET VDRLLPDLSA MPVLEGFDDA
120 GNARLRERRG KITLRHLLTH TSGLSYVFLH PLLREYMAQG HLQSAEKFGI QSRLAPPAVN
180 DPGAEWIYGA NLDWAGKLVE RATGLDLEQY LQENICAPLG ITDMTFKLQQ RPDMLARRAD
240 QTHRNSADGR LRYDDSVYFR ADGEECFGGQ GVFSGPGSYM KVLHSLLKRD GLLLQPQTVD
300 MMFQPALEPR LEEQMNQHMD ASPHINYGGP MPMVLRRSFG LGGIIALEDL DGEDWRRKGS
360 LTFGGGPNIV WQIDPKAGLC TLAFFQLEPW NDPVCRDLTR TFEHAIYAQY QQG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
820162
Alberts A.W.,Chen J.,Kuron G.,Hunt V.,Huff J.,Hoffman C.,Rothrock J.,Lopez M.,Joshua H.,Harris E.,Patchett A.,Monaghan R.,Currie S.,Stapley E.,Albers-Schonberg G.,Hensens O.,Hirshfield J.,Hoogsteen K.,Liesch J.,Springer J.
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Proc. Natl. Acad. Sci. U.S.A.
77
3957-3961
1980
820163
Hendrickson L.,Davis C.R.,Roach C.,Nguyen D.K.,Aldrich T.,McAda P.C.,Reeves C.D.
Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene.
Chem. Biol.
6
429-439
1999
820164
Kennedy J.,Auclair K.,Kendrew S.G.,Park C.,Vederas J.C.,Hutchinson C.R.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
Science
284
1368-1372
1999
820165
Sorensen J.L.,Auclair K.,Kennedy J.,Hutchinson C.R.,Vederas J.C.
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.
Org. Biomol. Chem.
1
50-59
2003
820166
Xie X.,Watanabe K.,Wojcicki W.A.,Wang C.C.,Tang Y.
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.
Chem. Biol.
13
1161-1169
2006
820167
Gao X.,Xie X.,Pashkov I.,Sawaya M.R.,Laidman J.,Zhang W.,Cacho R.,Yeates T.O.,Tang Y.
Directed evolution and structural characterization of a simvastatin synthase.
Chem. Biol.
16
1064-1074
2009
820168
Xie X.,Pashkov I.,Gao X.,Guerrero J.L.,Yeates T.O.,Tang Y.
Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.
Biotechnol. Bioeng.
102
20-28
2009
820169
Xie X.,Meehan M.J.,Xu W.,Dorrestein P.C.,Tang Y.
Acyltransferase mediated polyketide release from a fungal megasynthase.
J. Am. Chem. Soc.
131
8388-8389
2009
820170
Ma S.M.,Li J.W.,Choi J.W.,Zhou H.,Lee K.K.,Moorthie V.A.,Xie X.,Kealey J.T.,Da Silva N.A.,Vederas J.C.,Tang Y.
Complete reconstitution of a highly reducing iterative polyketide synthase.
Science
326
589-592
2009
820171
Meehan M.J.,Xie X.,Zhao X.,Xu W.,Tang Y.,Dorrestein P.C.
FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.
Biochemistry
50
287-299
2011
820172
Barriuso J.,Nguyen D.T.,Li J.W.,Roberts J.N.,MacNevin G.,Chaytor J.L.,Marcus S.L.,Vederas J.C.,Ro D.K.
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.
J. Am. Chem. Soc.
133
8078-8081
2011
820173
Ames B.D.,Nguyen C.,Bruegger J.,Smith P.,Xu W.,Ma S.,Wong E.,Wong S.,Xie X.,Li J.W.,Vederas J.C.,Tang Y.,Tsai S.C.
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc. Natl. Acad. Sci. U.S.A.
109
11144-11149
2012
820174
Xu W.,Chooi Y.H.,Choi J.W.,Li S.,Vederas J.C.,Da Silva N.A.,Tang Y.
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
Angew. Chem. Int. Ed. Engl.
52
6472-6475
2013
820175
Jimenez-Oses G.,Osuna S.,Gao X.,Sawaya M.R.,Gilson L.,Collier S.J.,Huisman G.W.,Yeates T.O.,Tang Y.,Houk K.N.
The role of distant mutations and allosteric regulation on LovD active site dynamics.
Nat. Chem. Biol.
10
431-436
2014
820176
Chen M.C.,Tsai Y.C.,Tseng J.H.,Liou J.J.,Horng S.,Wen H.C.,Fan Y.C.,Zhong W.B.,Hsu S.P.
Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer.
Int. J. Mol. Sci.
18
0-0
2017
820177
Zhong W.B.,Tsai Y.C.,Chin L.H.,Tseng J.H.,Tang L.W.,Horng S.,Fan Y.C.,Hsu S.P.
A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model.
Int. J. Mol. Sci.
19
0-0
2018
