Sequence of LOVA_ASPTN

monacolin L hydroxylase

Q0C8M4

528

60579

820061

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Sorensen J.L.,Auclair K.,Kennedy J.,Hutchinson C.R.,Vederas J.C.

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Org. Biomol. Chem.

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2003

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Xie X.,Watanabe K.,Wojcicki W.A.,Wang C.C.,Tang Y.

Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

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820066

Xie X.,Pashkov I.,Gao X.,Guerrero J.L.,Yeates T.O.,Tang Y.

Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.

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2009

820067

Gao X.,Xie X.,Pashkov I.,Sawaya M.R.,Laidman J.,Zhang W.,Cacho R.,Yeates T.O.,Tang Y.

Directed evolution and structural characterization of a simvastatin synthase.

Chem. Biol.

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2009

820068

Xie X.,Meehan M.J.,Xu W.,Dorrestein P.C.,Tang Y.

Acyltransferase mediated polyketide release from a fungal megasynthase.

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8388-8389

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820069

Ma S.M.,Li J.W.,Choi J.W.,Zhou H.,Lee K.K.,Moorthie V.A.,Xie X.,Kealey J.T.,Da Silva N.A.,Vederas J.C.,Tang Y.

Complete reconstitution of a highly reducing iterative polyketide synthase.

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820070

Meehan M.J.,Xie X.,Zhao X.,Xu W.,Tang Y.,Dorrestein P.C.

FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

Biochemistry

50

287-299

2011

820071

Barriuso J.,Nguyen D.T.,Li J.W.,Roberts J.N.,MacNevin G.,Chaytor J.L.,Marcus S.L.,Vederas J.C.,Ro D.K.

Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.

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2011

820072

Ames B.D.,Nguyen C.,Bruegger J.,Smith P.,Xu W.,Ma S.,Wong E.,Wong S.,Xie X.,Li J.W.,Vederas J.C.,Tang Y.,Tsai S.C.

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

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2012

820073

Xu W.,Chooi Y.H.,Choi J.W.,Li S.,Vederas J.C.,Da Silva N.A.,Tang Y.

LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

Angew. Chem. Int. Ed. Engl.

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6472-6475

2013

820074

Jimenez-Oses G.,Osuna S.,Gao X.,Sawaya M.R.,Gilson L.,Collier S.J.,Huisman G.W.,Yeates T.O.,Tang Y.,Houk K.N.

The role of distant mutations and allosteric regulation on LovD active site dynamics.

Nat. Chem. Biol.

10

431-436

2014

820075

Chen M.C.,Tsai Y.C.,Tseng J.H.,Liou J.J.,Horng S.,Wen H.C.,Fan Y.C.,Zhong W.B.,Hsu S.P.

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer.

Int. J. Mol. Sci.

18

0-0

2017

820076

Zhong W.B.,Tsai Y.C.,Chin L.H.,Tseng J.H.,Tang L.W.,Horng S.,Fan Y.C.,Hsu S.P.

A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model.

Int. J. Mol. Sci.

19

0-0

2018