Sequence of CP4F3_HUMAN

docosahexaenoic acid omega-hydroxylase

Q08477

520

59847

784030

Kikuta Y.,Kusunose E.,Endo K.,Yamamoto S.,Sogawa K.,Fujii-Kuriyama Y.,Kusunose M.

A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.

J. Biol. Chem.

268

9376-9380

1993

784031

Kikuta Y.,Kato M.,Yamashita Y.,Miyauchi Y.,Tanaka K.,Kamada N.,Kusunose M.

Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.

DNA Cell Biol.

17

221-230

1998

784033

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

784035

Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Nature

428

529-535

2004

784037

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

784038

Kikuta Y.,Kusunose E.,Sumimoto H.,Mizukami Y.,Takeshige K.,Sakaki T.,Yabusaki Y.,Kusunose M.

Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).

Arch. Biochem. Biophys.

355

201-205

1998

784039

Christmas P.,Ursino S.R.,Fox J.W.,Soberman R.J.

Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.

J. Biol. Chem.

274

21191-21199

1999

784040

Christmas P.,Jones J.P.,Patten C.J.,Rock D.A.,Zheng Y.,Cheng S.M.,Weber B.M.,Carlesso N.,Scadden D.T.,Rettie A.E.,Soberman R.J.

Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

J. Biol. Chem.

276

38166-38172

2001

784041

Le Quere V.,Plee-Gautier E.,Potin P.,Madec S.,Salauen J.P.

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

J. Lipid Res.

45

1446-1458

2004

784042

Kalsotra A.,Turman C.M.,Kikuta Y.,Strobel H.W.

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.

Toxicol. Appl. Pharmacol.

199

295-304

2004

784043

Sanders R.J.,Ofman R.,Duran M.,Kemp S.,Wanders R.J.

Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.

J. Biol. Chem.

281

13180-13187

2006

784044

Harmon S.D.,Fang X.,Kaduce T.L.,Hu S.,Raj Gopal V.,Falck J.R.,Spector A.A.

Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.

Prostaglandins Leukot. Essent. Fatty Acids

75

169-177

2006

784045

Sanders R.J.,Ofman R.,Dacremont G.,Wanders R.J.,Kemp S.

Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

FASEB J.

22

2064-2071

2008

784046

Dhar M.,Sepkovic D.W.,Hirani V.,Magnusson R.P.,Lasker J.M.

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

J. Lipid Res.

49

612-624

2008

784047

Fer M.,Corcos L.,Dreano Y.,Plee-Gautier E.,Salaun J.P.,Berthou F.,Amet Y.

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

J. Lipid Res.

49

2379-2389

2008