Sequence of OFUT2_HUMAN
EC Number:2.4.1.221
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
GDP-beta-L-fucose + PCQNGGSCKDQL = PCQNGGS(O-beta-L-fucosyl)-CKDQL + GDP
Other sequences found for EC No. 2.4.1.221
General information:
Sequence
0 MATLSFVFLL LGAVSWPPAS ASGQEFWPGQ SAADILSGAA SRRRYLLYDV NPPEGFNLRR
60 DVYIRIASLL KTLLKTEEWV LVLPPWGRLY HWQSPDIHQV RIPWSEFFDL PSLNKNIPVI
120 EYEQFIAESG GPFIDQVYVL QSYAEGWKEG TWEEKVDERP CIDQLLYSQD KHEYYRGWFW
180 GYEETRGLNV SCLSVQGSAS IVAPLLLRNT SARSVMLDRA ENLLHDHYGG KEYWDTRRSM
240 VFARHLREVG DEFRSRHLNS TDDADRIPFQ EDWMKMKVKL GSALGGPYLG VHLRRKDFIW
300 GHRQDVPSLE GAVRKIRSLM KTHRLDKVFV ATDAVRKEYE ELKKLLPEMV RFEPTWEELE
360 LYKDGGVAII DQWICAHARF FIGTSVSTFS FRIHEEREIL GLDPKTTYNR FCGDQEKACE
420 QPTHWKITY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
69688
Menzel O.,Vellai T.,Takacs-Vellai K.,Reymond A.,Mueller F.,Antonarakis S.E.,Guipponi M.
The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.
Genomics
84
320-330
2004
69689
Martinez-Duncker I.,Mollicone R.,Candelier J.-J.,Breton C.,Oriol R.
A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs.
Glycobiology
13
0-0
2003
69690
Nagase T.,Ishikawa K.,Suyama M.,Kikuno R.,Hirosawa M.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
DNA Res.
6
63-70
1999
69691
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
69692
Hattori M.,Fujiyama A.,Taylor T.D.,Watanabe H.,Yada T.,Park H.-S.,Toyoda A.,Ishii K.,Totoki Y.,Choi D.-K.,Groner Y.,Soeda E.,Ohki M.,Takagi T.,Sakaki Y.,Taudien S.,Blechschmidt K.,Polley A.,Menzel U.,Delabar J.,Kumpf K.,Lehmann R.,Patterson D.,Reichwald K.,Rump A.,Schillhabel M.,Schudy A.,Zimmermann W.,Rosenthal A.,Kudoh J.,Shibuya K.,Kawasaki K.,Asakawa S.,Shintani A.,Sasaki T.,Nagamine K.,Mitsuyama S.,Antonarakis S.E.,Minoshima S.,Shimizu N.,Nordsiek G.,Hornischer K.,Brandt P.,Scharfe M.,Schoen O.,Desario A.,Reichelt J.,Kauer G.,Bloecker H.,Ramser J.,Beck A.,Klages S.,Hennig S.,Riesselmann L.,Dagand E.,Wehrmeyer S.,Borzym K.,Gardiner K.,Nizetic D.,Francis F.,Lehrach H.,Reinhardt R.,Yaspo M.-L.
The DNA sequence of human chromosome 21.
Nature
405
311-319
2000
69693
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
69694
Hofsteenge J.,Huwiler K.G.,Macek B.,Hess D.,Lawler J.,Mosher D.F.,Peter-Katalinic J.
C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
J. Biol. Chem.
276
6485-6498
2001
69695
Luo Y.,Nita-Lazar A.,Haltiwanger R.S.
Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.
J. Biol. Chem.
281
9385-9392
2006
69696
Ricketts L.M.,Dlugosz M.,Luther K.B.,Haltiwanger R.S.,Majerus E.M.
O-fucosylation is required for ADAMTS13 secretion.
J. Biol. Chem.
282
17014-17023
2007
69697
Wang L.W.,Dlugosz M.,Somerville R.P.,Raed M.,Haltiwanger R.S.,Apte S.S.
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.
J. Biol. Chem.
282
17024-17031
2007
69698
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
69699
Chen C.I.,Keusch J.J.,Klein D.,Hess D.,Hofsteenge J.,Gut H.
Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation.
EMBO J.
31
3183-3197
2012
