Sequence of KTNA1_CAEEL

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
microtubule-severing ATPase
P34808
Caenorhabditis elegans
472
51739
Reaction
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MNGDVQSVIR GYLERAQVAK TMSDAGRWNE AGDLLRQLMT DVKSCKISAS NRDEHDARNT
 60 FLRALEANLK LVQQNVRDED DLHEAMTRQS GSPEPPADPD VWSKPSPPLP SSSKFGATKK
120 GVGAAGPRPR EISKSTSSMS TNPADVKPAN PTQGILPQNS AGDSFDASAY DAYIVQAVRG
180 TMATNTENTM SLDDIIGMHD VKQVLHEAVT LPLLVPEFFQ GLRSPWKAMV LAGPPGTGKT
240 LIARAIASES SSTFFTVSST DLSSKWRGDS EKIVRLLFEL ARFYAPSIIF IDEIDTLGGQ
300 RGNSGEHEAS RRVKSEFLVQ MDGSQNKFDS RRVFVLAATN IPWELDEALR RRFEKRIFIP
360 LPDIDARKKL IEKSMEGTPK SDEINYDDLA ARTEGFSGAD VVSLCRTAAI NVLRRYDTKS
420 LRGGELTAAM ESLKAELVRN IDFEAALQAV SPSAGPDTML KCKEWCDSFG AM
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
678227
Clark-Maguire S.,Mains P.E.
mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases.
Genetics
136
533-546
1994
678228
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
678229
Clark-Maguire S.,Mains P.E.
Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component.
J. Cell Biol.
126
199-209
1994
678230
Srayko M.,Buster D.W.,Bazirgan O.A.,McNally F.J.,Mains P.E.
MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis.
Genes Dev.
14
1072-1084
2000
678231
Kurz T.,Pintard L.,Willis J.H.,Hamill D.R.,Goenczy P.,Peter M.,Bowerman B.
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.
Science
295
1294-1298
2002
678232
Pintard L.,Kurz T.,Glaser S.,Willis J.H.,Peter M.,Bowerman B.
Neddylation and deneddylation of CUL-3 is required to target MEI-1/katanin for degradation at the meiosis-to-mitosis transition in C. elegans.
Curr. Biol.
13
911-921
2003
678233
Yang H.-Y.,McNally K.,McNally F.J.
MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.
Dev. Biol.
260
245-259
2003
678234
Pintard L.,Willis J.H.,Willems A.,Johnson J.-L.F.,Srayko M.,Kurz T.,Glaser S.,Mains P.E.,Tyers M.,Bowerman B.,Peter M.
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Nature
425
311-316
2003
678235
Furukawa M.,He Y.J.,Borchers C.,Xiong Y.
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Nat. Cell Biol.
5
1001-1007
2003
678236
Stitzel M.L.,Pellettieri J.,Seydoux G.
The C. elegans DYRK Kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation.
Curr. Biol.
16
56-62
2006
678237
Han X.,Gomes J.E.,Birmingham C.L.,Pintard L.,Sugimoto A.,Mains P.E.
The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo.
Genetics
181
933-943
2009
678238
Wilson K.J.,Qadota H.,Mains P.E.,Benian G.M.
UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
Mol. Biol. Cell
23
2623-2634
2012
678239
Gomes J.E.,Tavernier N.,Richaudeau B.,Formstecher E.,Boulin T.,Mains P.E.,Dumont J.,Pintard L.
Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation.
J. Cell Biol.
202
431-439
2013
678240
Zehr E.,Szyk A.,Piszczek G.,Szczesna E.,Zuo X.,Roll-Mecak A.
Katanin spiral and ring structures shed light on power stroke for microtubule severing.
Nat. Struct. Mol. Biol.
24
717-725
2017