Sequence of ACE2_MOUSE

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
angiotensin-converting enzyme 2
Q8R0I0
Mus musculus
805
92368
Reaction
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSSSSWLLLS LVAVTTAQSL TEENAKTFLN NFNQEAEDLS YQSSLASWNY NTNITEENAQ
 60 KMSEAAAKWS AFYEEQSKTA QSFSLQEIQT PIIKRQLQAL QQSGSSALSA DKNKQLNTIL
120 NTMSTIYSTG KVCNPKNPQE CLLLEPGLDE IMATSTDYNS RLWAWEGWRA EVGKQLRPLY
180 EEYVVLKNEM ARANNYNDYG DYWRGDYEAE GADGYNYNRN QLIEDVERTF AEIKPLYEHL
240 HAYVRRKLMD TYPSYISPTG CLPAHLLGDM WGRFWTNLYP LTVPFAQKPN IDVTDAMMNQ
300 GWDAERIFQE AEKFFVSVGL PHMTQGFWAN SMLTEPADGR KVVCHPTAWD LGHGDFRIKM
360 CTKVTMDNFL TAHHEMGHIQ YDMAYARQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS
420 IGLLPSDFQE DSETEINFLL KQALTIVGTL PFTYMLEKWR WMVFRGEIPK EQWMKKWWEM
480 KREIVGVVEP LPHDETYCDP ASLFHVSNDY SFIRYYTRTI YQFQFQEALC QAAKYNGSLH
540 KCDISNSTEA GQKLLKMLSL GNSEPWTKAL ENVVGARNMD VKPLLNYFQP LFDWLKEQNR
600 NSFVGWNTEW SPYADQSIKV RISLKSALGA NAYEWTNNEM FLFRSSVAYA MRKYFSIIKN
660 QTVPFLEEDV RVSDLKPRVS FYFFVTSPQN VSDVIPRSEV EDAIRMSRGR INDVFGLNDN
720 SLEFLGIHPT LEPPYQPPVT IWLIIFGVVM ALVVVGIIIL IVTGIKGRKK KNETKREENP
780 YDSMDIGKGE SNAGFQNSDD AQTSF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
618721
Komatsu T.,Suzuki Y.,Imai J.,Sugano S.,Hida M.,Tanigami A.,Muroi S.,Yamada Y.,Hanaoka K.
Molecular cloning, mRNA expression, and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2).
DNA Seq.
13
217-220
2002
618722
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
618723
Crackower M.A.,Sarao R.,Oudit G.Y.,Yagil C.,Kozieradzki I.,Scanga S.E.,Oliveira-dos-Santos A.J.,da Costa J.,Zhang L.,Pei Y.,Scholey J.,Ferrario C.M.,Manoukian A.S.,Chappell M.C.,Backx P.H.,Yagil Y.,Penninger J.M.
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Nature
417
822-828
2002
618724
Donoghue M.,Wakimoto H.,Maguire C.T.,Acton S.,Hales P.,Stagliano N.,Fairchild-Huntress V.,Xu J.,Lorenz J.N.,Kadambi V.,Berul C.I.,Breitbart R.E.
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins.
J. Mol. Cell. Cardiol.
35
1043-1053
2003
618725
Li W.,Greenough T.C.,Moore M.J.,Vasilieva N.,Somasundaran M.,Sullivan J.L.,Farzan M.,Choe H.
Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.
J. Virol.
78
11429-11433
2004
618726
Imai Y.,Kuba K.,Rao S.,Huan Y.,Guo F.,Guan B.,Yang P.,Sarao R.,Wada T.,Leong-Poi H.,Crackower M.A.,Fukamizu A.,Hui C.-C.,Hein L.,Uhlig S.,Slutsky A.S.,Jiang C.,Penninger J.M.
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Nature
436
112-116
2005
618727
Gembardt F.,Sterner-Kock A.,Imboden H.,Spalteholz M.,Reibitz F.,Schultheiss H.-P.,Siems W.-E.,Walther T.
Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents.
Peptides
26
1270-1277
2005
618728
Kowalczuk S.,Broeer A.,Tietze N.,Vanslambrouck J.M.,Rasko J.E.,Broeer S.
A protein complex in the brush-border membrane explains a Hartnup disorder allele.
FASEB J.
22
2880-2887
2008
618729
Camargo S.M.,Singer D.,Makrides V.,Huggel K.,Pos K.M.,Wagner C.A.,Kuba K.,Danilczyk U.,Skovby F.,Kleta R.,Penninger J.M.,Verrey F.
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Gastroenterology
136
872-882
2009
618730
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
618731
Fairweather S.J.,Broeer A.,O'Mara M.L.,Broeer S.
Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
Biochem. J.
446
135-148
2012
618732
Xiao L.,Haack K.K.,Zucker I.H.
Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling.
Am. J. Physiol.
304
0-0
2013