Sequence of ACE2_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
angiotensin-converting enzyme 2
Q9BYF1
Homo sapiens
805
92463
Reaction
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ
 60 NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL
120 NTMSTIYSTG KVCNPDNPQE CLLLEPGLNE IMANSLDYNE RLWAWESWRS EVGKQLRPLY
180 EEYVVLKNEM ARANHYEDYG DYWRGDYEVN GVDGYDYSRG QLIEDVEHTF EEIKPLYEHL
240 HAYVRAKLMN AYPSYISPIG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVDQ
300 AWDAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KAVCHPTAWD LGKGDFRILM
360 CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS
420 IGLLSPDFQE DNETEINFLL KQALTIVGTL PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM
480 KREIVGVVEP VPHDETYCDP ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH
540 KCDISNSTEA GQKLFNMLRL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK
600 NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN
660 QMILFGEEDV RVANLKPRIS FNFFVTAPKN VSDIIPRTEV EKAIRMSRSR INDAFRLNDN
720 SLEFLGIQPT LGPPNQPPVS IWLIVFGVVM GVIVVGIVIL IFTGIRDRKK KNKARSGENP
780 YASIDISKGE NNPGFQNTDD VQTSF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
618689
Donoghue M.,Hsieh F.,Baronas E.,Godbout K.,Gosselin M.,Stagliano N.,Donovan M.,Woolf B.,Robison K.,Jeyaseelan R.,Breitbart R.E.,Acton S.
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
Circ. Res.
87
0-0
2000
618690
Tipnis S.R.,Hooper N.M.,Hyde R.,Karran E.,Christie G.,Turner A.J.
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
J. Biol. Chem.
275
33238-33243
2000
618691
Douglas G.C.,O'Bryan M.K.,Hedger M.P.,Lee D.K.L.,Yarski M.A.,Smith A.I.,Lew R.A.
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.
Endocrinology
145
4703-4711
2004
618692
Itoyama S.,Keicho N.,Hijikata M.,Quy T.,Phi N.C.,Long H.T.,Ha L.D.,Ban V.V.,Matsushita I.,Yanai H.,Kirikae F.,Kirikae T.,Kuratsuji T.,Sasazuki T.
Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.
Am. J. Med. Genet. A
136
52-57
2005
618696
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
618699
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
618700
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
618701
Lin Q.,Keller R.S.,Weaver B.,Zisman L.S.
Interaction of ACE2 and integrin beta1 in failing human heart.
Biochim. Biophys. Acta
1689
175-178
2004
618702
Harmer D.,Gilbert M.,Borman R.,Clark K.L.
Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.
FEBS Lett.
532
107-110
2002
618703
Vickers C.,Hales P.,Kaushik V.,Dick L.,Gavin J.,Tang J.,Godbout K.,Parsons T.,Baronas E.,Hsieh F.,Acton S.,Patane M.A.,Nichols A.,Tummino P.
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
J. Biol. Chem.
277
14838-14843
2002
618704
Li W.,Moore M.J.,Vasilieva N.,Sui J.,Wong S.-K.,Berne M.A.,Somasundaran M.,Sullivan J.L.,Luzuriaga K.,Greenough T.C.,Choe H.,Farzan M.
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Nature
426
450-454
2003
618705
Goulter A.B.,Goddard M.J.,Allen J.C.,Clark K.L.
ACE2 gene expression is up-regulated in the human failing heart.
BMC Med.
2
19-19
2004
618706
Hamming I.,Timens W.,Bulthuis M.L.C.,Lely A.T.,Navis G.J.,van Goor H.
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
J. Pathol.
203
631-637
2004
618707
Li W.,Greenough T.C.,Moore M.J.,Vasilieva N.,Somasundaran M.,Sullivan J.L.,Farzan M.,Choe H.
Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.
J. Virol.
78
11429-11433
2004
618708
Kristiansen T.Z.,Bunkenborg J.,Gronborg M.,Molina H.,Thuluvath P.J.,Argani P.,Goggins M.G.,Maitra A.,Pandey A.
A proteomic analysis of human bile.
Mol. Cell. Proteomics
3
715-728
2004
618709
Burrell L.M.,Risvanis J.,Kubota E.,Dean R.G.,MacDonald P.S.,Lu S.,Tikellis C.,Grant S.L.,Lew R.A.,Smith A.I.,Cooper M.E.,Johnston C.I.
Myocardial infarction increases ACE2 expression in rat and humans.
Eur. Heart J.
26
369-375
2005
618710
Li W.,Zhang C.,Sui J.,Kuhn J.H.,Moore M.J.,Luo S.,Wong S.-K.,Huang I.-C.,Xu K.,Vasilieva N.,Murakami A.,He Y.,Marasco W.A.,Guan Y.,Choe H.,Farzan M.
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.
EMBO J.
24
1634-1643
2005
618711
Lambert D.W.,Yarski M.,Warner F.J.,Thornhill P.,Parkin E.T.,Smith A.I.,Hooper N.M.,Turner A.J.
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
J. Biol. Chem.
280
30113-30119
2005
618712
Hofmann H.,Pyrc K.,van der Hoek L.,Geier M.,Berkhout B.,Poehlmann S.
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry.
Proc. Natl. Acad. Sci. U.S.A.
102
7988-7993
2005
618713
Kowalczuk S.,Broeer A.,Tietze N.,Vanslambrouck J.M.,Rasko J.E.,Broeer S.
A protein complex in the brush-border membrane explains a Hartnup disorder allele.
FASEB J.
22
2880-2887
2008
618714
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
618715
Camargo S.M.,Singer D.,Makrides V.,Huggel K.,Pos K.M.,Wagner C.A.,Kuba K.,Danilczyk U.,Skovby F.,Kleta R.,Penninger J.M.,Verrey F.
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Gastroenterology
136
872-882
2009
618716
Lai Z.W.,Hanchapola I.,Steer D.L.,Smith A.I.
Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints.
Biochemistry
50
5182-5194
2011
618717
Shulla A.,Heald-Sargent T.,Subramanya G.,Zhao J.,Perlman S.,Gallagher T.
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.
J. Virol.
85
873-882
2011
618718
Heurich A.,Hofmann-Winkler H.,Gierer S.,Liepold T.,Jahn O.,Poehlmann S.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
J. Virol.
88
1293-1307
2014
618719
Towler P.,Staker B.,Prasad S.G.,Menon S.,Tang J.,Parsons T.,Ryan D.,Fisher M.,Williams D.,Dales N.A.,Patane M.A.,Pantoliano M.W.
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J. Biol. Chem.
279
17996-18007
2004