Sequence of R1AB_CVPPU
EC Number:3.4.19.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ubiquitinyl hydrolase 1
P0C6Y5
Porcine transmissible gastroenteritis coronavirus (strain Purdue)
6684
748912
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12
General information:
Sequence
0 MSSKQFKILV NEDYQVNVPS LPIRDVLQEI KYCYRNGFEG YVFVPEYCRD LVDCDRKDHY
60 VIGVLGNGVS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF DLKIARTGRG AIYVDQYMCG
120 ADGKPVIEGD FKDYFGDEDI IEFEGEEYHC AWTTVRDEKP LNQQTLFTIQ EIQYNLDIPH
180 KLPNCATRHV APPVKKNSKI VLSEDYKKLY DIFGSPFMGN GDCLSKCFDT LHFIAATLRC
240 PCGSESSGVG DWTGFKTACC GLSGKVKGVT LGDIKPGDAV VTSMSAGKGV KFFANCVLQY
300 AGDVEGVSIW KVIKTFTVDE TVCTPGFEGE LNDFIKPESK SLVACSVKRA FITGDIDDAV
360 HDCIITGKLD LSTNLFGNVG LLFKKTPWFV QKCGALFVDA WKVVEELCGS LTLTYKQIYE
420 VVASLCTSAF TIVNYKPTFV VPDNRVKDLV DKCVKVLVKA FDVFTQIITI AGIEAKCFVL
480 GAKYLLFNNA LVKLVSVKIL GKKQKGLECA FFATSLVGAT VNVTPKRTET ATISLNKVDD
540 VVAPGEGYIV IVGDMAFYKS GEYYFMMSSP NFVLTNNVFK AVKVPSYDIV YDVDNDTKSK
600 MIAKLGSSFE YDGDIDAAIV KVNELLIEFR QQSLCFRAFK DDKSIFVEAY FKKYKMPACL
660 AKHIGLWNII KKDSCKRGFL NLFNHLNELE DIKETNIQAI KNILCPDPLL DLDYGAIWYN
720 CMPGCSDPSV LGSVQLLIGN GVKVVCDGCK GFANQLSKGY NKLCNAARND IEIGGIPFST
780 FKTPTNTFIE MTDAIYSVIE QGKALSFRDA DVPVVDNGTI STADWSEPIL LEPAEYVKPK
840 NNGNVIVIAG YTFYKDEDEH FYPYGFGKIV QRMYNKMGGG DKTVSFSEEV DVQEIAPVTR
900 VKLEFEFDNE IVTGVLERAI GTRYKFTGTT WEEFEESISE ELDAIFDTLA NQGVELEGYF
960 IYDTCGGFDI KNPDGIMISQ YDINITADEK SEVSASSEEE EVESVEEDPE NEIVEASEGA
1020 EGTSSQEEVE TVEVADITST EEDVDIVEVS AKDDPWAAAV DVQEAEQFNP SLPPFKTTNL
1080 NGKIILKQGD NNCWINACCY QLQAFDFFNN EAWEKFKKGD VMDFVNLCYA ATTLARGHSG
1140 DAEYLLELML NDYSTAKIVL AAKCGCGEKE IVLERAVFKL TPLKESFNYG VCGDCMQVNT
1200 CRFLSVEGSG VFVHDILSKQ TPEAMFVVKP VMHAVYTGTT QNGHYMVDDI EHGYCVDGMG
1260 IKPLKKRCYT STLFINANVM TRAEKPKQEF KVEKVEQQPI VEENKSSIEK EEIQSPKNDD
1320 LILPFYKAGK LSFYQGALDV LINFLEPDVI VNAANGDLKH MGGVARAIDV FTGGKLTERS
1380 KDYLKKNKSI APGNAVFFEN VIEHLSVLNA VGPRNGDSRV EAKLCNVYKA IAKCEGKILT
1440 PLISVGIFNV RLETSLQCLL KTVNDRGLNV FVYTDQERQT IENFFSCSIP VNVTEDNVNH
1500 ERVSVSFDKT YGEQLKGTVV IKDKDVTNQL PSAFDVGQKV IKAIDIDWQA HYGFRDAAAF
1560 SASSHDAYKF EVVTHSNFIV HKQTDNNCWI NAICLALQRL KPQWKFPGVR GLWNEFLERK
1620 TQGFVHMLYH ISGVKKGEPG DAELMLHKLG DLMDNDCEII VTHTTACDKC AKVEKFVGPV
1680 VAAPLAIHGT DETCVHGVSV NVKVTQIKGT VAITSLIGPI IGEVLEATGY ICYSGSNRNG
1740 HYTYYDNRNG LVVDAEKAYH FNRDLLQVTT AIASNFVVKK PQAEERPKNC AFNKVAASPK
1800 IVQEQKLLAI ESGANYALTE FGRYADMFFM AGDKILRLLL EVFKYLLVLF MCLRSTKMPK
1860 VKVKPPLAFK DFGAKVRTLN YMRQLNKPSV WRYAKLVLLL IAIYNFFYLF VSIPVVHKLT
1920 CNGAVQAYKN SSFIKSAVCG NSILCKACLA SYDELADFQH LQVTWDFKSD PLWNRLVQLS
1980 YFAFLAVFGN NYVRCFLMYF VSQYLNLWLS YFGYVEYSWF LHVVNFESIS AEFVIVVIVV
2040 KAVLALKHIV FACSNPSCKT CSRTARQTRI PIQVVVNGSM KTVYVHANGT GKFCKKHNFY
2100 CKNCDSYGFE NTFICDEIVR DLSNSVKQTV YATDRSHQEV TKVECSDGFY RFYVGDEFTS
2160 YDYDVKHKKY SSQEVLKSML LLDDFIVYSP SGSALANVRN ACVYFSQLIG KPIKIVNSDL
2220 LEDLSVDFKG ALFNAKKNVI KNSFNVDVSE CKNLDECYRA CNLNVSFSTF EMAVNNAHRF
2280 GILITDRSFN NFWPSKVKPG SSGVSAMDIG KCMTSDAKIV NAKVLTQRGK SVVWLSQDFA
2340 ALSSTAQKVL VKTFVEEGVN FSLTFNAVGS DDDLPYERFT ESVSPKSGSG FFDVITQLKQ
2400 IVILVFVFIF ICGLCSVYSV ATQSYIESAE GYDYMVIKNG IVQPFDDTIS CVHNTYKGFG
2460 DWFKAKYGFI PTFGKSCPIV VGTVFDLENM RPIPDVPAYV SIVGRSLVFA INAAFGVTNM
2520 CYDHTGNAVS KDSYFDTCVF NTACTTLTGL GGTIVYCAKQ GLVEGAKLYS DLMPDYYYEH
2580 ASGNMVKLPA IIRGLGLRFV KTQATTYCRV GECIDSKAGF CFGGDNWFVY DNEFGNGYIC
2640 GNSVLGFFKN VFKLFNSNMS VVATSGAMLV NIIIACLAIA MCYGVLKFKK IFGDCTFLIV
2700 MIIVTLVVNN VSYFVTQNTF FMIIYAIVYY FITRKLAYPG ILDAGFIIAY INMAPWYVIT
2760 AYILVFLYDS LPSLFKLKVS TNLFEGDKFV GNFESAAMGT FVIDMRSYET IVNSTSIARI
2820 KSYANSFNKY KYYTGSMGEA DYRMACYAHL GKALMDYSVN RTDMLYTPPT VSVNSTLQSG
2880 LRKMAQPSGL VEPCIVRVSY GNNVLNGLWL GDEVICPRHV IASDTTRVIN YENEMSSVRL
2940 HNFSVSKNNV FLGVVSARYK GVNLVLKVNQ VNPNTPEHKF KSIKAGESFN ILACYEGCPG
3000 SVYGVNMRSQ GTIKGSFIAG TCGSVGYVLE NGILYFVYMH HLELGNGSHV GSNFEGEMYG
3060 GYEDQPSMQL EGTNVMSSDN VVAFLYAALI NGERWFVTNT SMSLESYNTW AKTNSFTELS
3120 STDAFSMLAA KTGQSVEKLL DSIVRLNKGF GGRTILSYGS LCDEFTPTEV IRQMYGVNLQ
3180 AGKVKSFFYP IMTAMTILFA FWLEFFMYTP FTWINPTFVS IVLAVTTLIS TVFVSGIKHK
3240 MLFFMSFVLP SVILVTAHNL FWDFSYYESL QSIVENTNTM FLPVDMQGVM LTVFCFIVFV
3300 TYSVRFFTCK QSWFSLAVTT ILVIFNMVKI FGTSDEPWTE NQIAFCFVNM LTMIVSLTTK
3360 DWMVVIASYR IAYYIVVCVM PSAFVSDFGF MKCISIVYMA CGYLFCCYYG ILYWVNRFTC
3420 MTCGVYQFTV SAAELKYMTA NNLSAPKNAY DAMILSAKLI GVGGKRNIKI STVQSKLTEM
3480 KCTNVVLLGL LSKMHVESNS KEWNYCVGLH NEINLCDDPE IVLEKLLALI AFFLSKHNTC
3540 DLSELIESYF ENTTILQSVA SAYAALPSWI ALEKARADLE EAKKNDVSPQ ILKQLTKAFN
3600 IAKSDFEREA SVQKKLDKMA EQAAASMYKE ARAVDRKSKI VSAMHSLLFG MLKKLDMSSV
3660 NTIIDQARNG VLPLSIIPAA SATRLVVITP SLEVFSKIRQ ENNVHYAGAI WTIVEVKDAN
3720 GSHVHLKEVT AANELNLTWP LSITCERTTK LQNNEIMPGK LKERAVRASA TLDGEAFGSG
3780 KALMASESGK SFMYAFIASD NNLKYVKWES NNDIIPIELE APLRFYVDGA NGPEVKYLYF
3840 VKNLNTLRRG AVLGYIGATV RLQAGKPTEH PSNSSLLTLC AFSPDPAKAY VDAVKRGMQP
3900 VNNCVKMLSN GAGNGMAVTN GVEANTQQDS YGGASVCIYC RCHVEHPAID GLCRYKGKFV
3960 QIPTGTQDPI RFCIENEVCV VCGCWLNNGC MCDRTSMQSF TVDQSYLNRV RGSSAARLEP
4020 CNGTDPDHVS RAFDIYNKDV ACIGKFLKTN CSRFRNLDKH DAYYIVKRCT KTVMDHEQVC
4080 YNDLKDSGAV AEHDFFTYKE GRCEFGNVAR RNLTKYTMMD LCYAIRNFDE KNCEVLKEIL
4140 VTVGACTEEF FENKDWFDPV ENEAIHEVYA KLGPIVANAM LKCVAFCDAI VEKGYIGVIT
4200 LDNQDLNGNF YDFGDFVKTA PGFGCACVTS YYSYMMPLMG MTSCLESENF VKSDIYGSDY
4260 KQYDLLAYDF TEHKEYLFQK YFKYWDRTYH PNCSDCTSDE CIIHCANFNT LFSMTIPMTA
4320 FGPLVRKVHI DGVPVVVTAG YHFKQLGIVW NLDVKLDTMK LSMTDLLRFV TDPTLLVASS
4380 PALLDQRTVC FSIAALSTGI TYQTVKPGHF NKDFYDFITE RGFFEEGSEL TLKHFFFAQG
4440 GEAAMTDFNY YRYNRVTVLD ICQAQFVYKI VGKYFECYDG GCINAREVVV TNYDKSAGYP
4500 LNKFGKARLY YETLSYEEQD ALFALTKRNV LPTMTQMNLK YAISGKARAR TVGGVSLLST
4560 MTTRQYHQKH LKSIAATRNA TVVIGSTKFY GGWDNMLKNL MRDVDNGCLM GWDYPKCDRA
4620 LPNMIRMASA MILGSKHVGC CTHNDRFYRL SNELAQVLTE VVHCTGGFYF KPGGTTSGDG
4680 TTAYANSAFN IFQAVSANVN KLLGVDSNAC NNVTVKSIQR KIYDNCYRSS SIDEEFVVEY
4740 FSYLRKHFSM MILSDDGVVC YNKDYADLGY VADINAFKAT LYYQNNVFMS TSKCWVEPDL
4800 SVGPHEFCSQ HTLQIVGPDG DYYLPYPDPS RILSAGVFVD DIVKTDNVIM LERYVSLAID
4860 AYPLTKHPKP AYQKVFYTLL DWVKHLQKNL NAGVLDSFSV TMLEEGQDKF WSEEFYASLY
4920 EKSTVLQAAG MCVVCGSQTV LRCGDCLRRP LLCTKCAYDH VMGTKHKFIM SITPYVCSFN
4980 GCNVNDVTKL FLGGLSYYCM NHKPQLSFPL CANGNVFGLY KSSAVGSEAV EDFNKLAVSD
5040 WTNVEDYKLA NNVKESLKIF AAETVKAKEE SVKSEYAYAV LKEVIGPKEI VLQWEASKTK
5100 PPLNRNSVFT CFQISKDTKI QLGEFVFEQS EYGSDSVYYK STSTYKLTPG MIFVLTSHNV
5160 SPLKAPILVN QEKYNTISKL YPVFNIAEAY NTLVPYYQMI GKQKFTTIQG PPGSGKSHCV
5220 IGLGLYYPQA RIVYTACSHA AVDALCEKAA KNFNVDRCSR IIPQRIRVDC YTGFKPNNTN
5280 AQYLFCTVNA LPEASCDIVV VDEVSMCTNY DLSVINSRLS YKHIVYVGDP QQLPAPRTLI
5340 NKGVLQPQDY NVVTKRMCTL GPDVFLHKCY RCPAEIVKTV SALVYENKFV PVNPESKQCF
5400 KMFVKGQVQI ESNSSINNKQ LEVVKAFLAH NPKWRKAVFI SPYNSQNYVA RRLLGLQTQT
5460 VDSAQGSEYD YVIYTQTSDT QHATNVNRFN VAITRAKVGI LCIMCDRTMY ENLDFYELKD
5520 SKIGLQAKPE TCGLFKDCSK SEQYIPPAYA TTYMSLSDNF KTSDGLAVNI GTKDVKYANV
5580 ISYMGFRFEA NIPGYHTLFC TRDFAMRNVR AWLGFDVEGA HVCGDNVGTN VPLQLGFSNG
5640 VDFVVQTEGC VITEKGNSIE VVKARAPPGE QFAHLIPLMR KGQPWHIVRR RIVQMVCDYF
5700 DGLSDILIFV LWAGGLELTT MRYFVKIGRP QKCECGKSAT CYSSSQSVYA CFKHALGCDY
5760 LYNPYCIDIQ QWGYTGSLSM NHHEVCNIHR NEHVASGDAI MTRCLAIHDC FVKRVDWSIV
5820 YPFIDNEEKI NKAGRIVQSH VMKAALKIFN PAAIHDVGNP KGIRCATTPI PWFCYDRDPI
5880 NNNVRCLDYD YMVHGQMNGL MLFWNCNVDM YPEFSIVCRF DTRTRSKLSL EGCNGGALYV
5940 NNHAFHTPAY DRRAFAKLKP MPFFYYDDSN CELVDGQPNY VPLKSNVCIT KCNIGGAVCK
6000 KHAALYRAYV EDYNIFMQAG FTIWCPQNFD TYMLWHGFVN SKALQSLENV AFNVVKKGAF
6060 TGLKGDLPTA VIADKIMVRD GPTDKCIFTN KTSLPTNVAF ELYAKRKLGL TPPLTILRNL
6120 GVVATYKFVL WDYEAERPFS NFTKQVCSYT DLDSEVVTCF DNSIAGSFER FTTTRDAVLI
6180 SNNAVKGLSA IKLQYGLLND LPVSTVGNKP VTWYIYVRKN GEYVEQIDSY YTQGRTFETF
6240 KPRSTMEEDF LSMDTTLFIQ KYGLEDYGFE HVVFGDVSKT TIGGMHLLIS QVRLAKMGLF
6300 SVQEFMNNSD STLKSCCITY ADDPSSKNVC TYMDILLDDF VTIIKSLDLN VVSKVVDVIV
6360 DCKAWRWMLW CENSHIKTFY PQLQSAEWNP GYSMPTLYKI QRMCLERCNL YNYGAQVKLP
6420 DGITTNVVKY TQLCQYLNTT TLCVPHKMRV LHLGAAGASG VAPGSTVLRR WLPDDAILVD
6480 NDLRDYVSDA DFSVTGDCTS LYIEDKFDLL VSDLYDGSTK SIDGENTSKD GFFTYINGFI
6540 KEKLSLGGSV AIKITEFSWN KDLYELIQRF EYWTVFCTSV NTSSSEGFLI GINYLGPYCD
6600 KAIVDGNIMH ANYIFWRNST IMALSHNSVL DTPKFKCRCN NALIVNLKEK ELNEMVIGLL
6660 RKGKLLIRNN GKLLNFGNHF VNTP
Download this sequence
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
594271
Eleouet J.,Rasschaert D.,Lambert P.,Levy L.,Vende P.,Laude H.
Complete sequence (20 kilobases) of the polyprotein-encoding gene 1 of transmissible gastroenteritis virus.
Virology
206
817-822
1995
594272
Almazan F.,Gonzalez J.M.,Penzes Z.,Izeta A.,Calvo E.,Plana-Duran J.,Enjuanes L.
Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome.
Proc. Natl. Acad. Sci. U.S.A.
97
5516-5521
2000
594273
Hegyi A.,Ziebuhr J.
Conservation of substrate specificities among coronavirus main proteases.
J. Gen. Virol.
83
595-599
2002
594274
Huang C.,Lokugamage K.G.,Rozovics J.M.,Narayanan K.,Semler B.L.,Makino S.
Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate.
J. Virol.
85
638-643
2011
594275
Anand K.,Palm G.J.,Mesters J.R.,Siddell S.G.,Ziebuhr J.,Hilgenfeld R.
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J.
21
3213-3224
2002
594276
Anand K.,Ziebuhr J.,Wadhwani P.,Mesters J.R.,Hilgenfeld R.
Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.
Science
300
1763-1767
2003
