Sequence of PGDH_HUMAN

15-hydroxyicosatetraenoate dehydrogenase

P15428

266

28977

585379

Krook M.,Marekov L.,Joernvall H.

Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family.

Biochemistry

29

738-743

1990

585380

Ensor C.M.,Yang J.Y.,Okita R.T.,Tai H.-H.

Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

J. Biol. Chem.

265

14888-14891

1990

585381

Pichaud F.,Frendo J.L.,Delage-Mourroux R.,de Vernejoul M.C.,Moukhtar M.S.,Jullienne A.

Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

Gene

162

319-322

1995

585382

Delage-Mourroux R.,Pichaud F.,Frendo J.L.,Pidoux E.,Guliana J.M.,Moukhtar M.S.,Jullienne A.

Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA.

Gene

188

143-148

1997

585383

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

585385

Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Nature

434

724-731

2005

585387

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

585388

Ensor C.M.,Tai H.-H.

Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme.

Biochem. Biophys. Res. Commun.

176

840-845

1991

585389

Ensor C.M.,Tai H.H.

Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

Biochim. Biophys. Acta

1208

151-156

1994

585390

Clish C.B.,Levy B.D.,Chiang N.,Tai H.-H.,Serhan C.N.

Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation.

J. Biol. Chem.

275

25372-25380

2000

585391

Patel F.A.,Funder J.W.,Challis J.R.G.

Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term.

J. Clin. Endocrinol. Metab.

88

2922-2933

2003

585392

Nomura T.,Lu R.,Pucci M.L.,Schuster V.L.

The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase.

Mol. Pharmacol.

65

973-978

2004

585393

Yan M.,Rerko R.M.,Platzer P.,Dawson D.,Willis J.,Tong M.,Lawrence E.,Lutterbaugh J.,Lu S.,Willson J.K.V.,Luo G.,Hensold J.,Tai H.-H.,Wilson K.,Markowitz S.D.

15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

Proc. Natl. Acad. Sci. U.S.A.

101

17468-17473

2004

585394

Cho H.,Huang L.,Hamza A.,Gao D.,Zhan C.-G.,Tai H.-H.

Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.

Bioorg. Med. Chem.

14

6486-6491

2006

585395

Arita M.,Oh S.F.,Chonan T.,Hong S.,Elangovan S.,Sun Y.P.,Uddin J.,Petasis N.A.,Serhan C.N.

Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions.

J. Biol. Chem.

281

22847-22854

2006

585396

Liu X.,Zhang S.,Arora J.S.,Snyder N.W.,Shah S.J.,Blair I.A.

11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

Chem. Res. Toxicol.

24

2227-2236

2011

585397

Claria J.,Dalli J.,Yacoubian S.,Gao F.,Serhan C.N.

Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.

J. Immunol.

189

2597-2605

2012

585398

Wendell S.G.,Golin-Bisello F.,Wenzel S.,Sobol R.W.,Holguin F.,Freeman B.A.

15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids.

J. Biol. Chem.

290

5868-5880

2015

585399

Krook M.,Ghosh D.,Duax W.L.,Joernvall H.

Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase).

FEBS Lett.

322

139-142

1993

585400

Uppal S.,Diggle C.P.,Carr I.M.,Fishwick C.W.G.,Ahmed M.,Ibrahim G.H.,Helliwell P.S.,Latos-Bielenska A.,Phillips S.E.V.,Markham A.F.,Bennett C.P.,Bonthron D.T.

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.

Nat. Genet.

40

789-793

2008

585402

Niesen F.H.,Schultz L.,Jadhav A.,Bhatia C.,Guo K.,Maloney D.J.,Pilka E.S.,Wang M.,Oppermann U.,Heightman T.D.,Simeonov A.

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

PLoS ONE

5

0-0

2010

585403

Tariq M.,Azeem Z.,Ali G.,Chishti M.S.,Ahmad W.

Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC).

J. Med. Genet.

46

14-20

2009