Sequence of MRP1_HUMAN

ABC-type glutathione-S-conjugate transporter

P33527

1531

171591

571837

Cole S.P.C.,Bhardwaj G.,Gerlach J.H.,Mackie J.E.,Grant C.E.,Almquist K.C.,Stewart A.J.,Kurz E.U.,Duncan A.M.V.,Deeley R.G.

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.

Science

258

1650-1654

1992

571838

Cole S.P.C.,Deeley R.G.

Multidrug resistance-associated protein: sequence correction.

Science

260

879-879

1993

571839

Grant C.E.,Kurz E.U.,Cole S.P.C.,Deeley R.G.

Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA.

Genomics

45

368-378

1997

571841

Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.

The sequence and analysis of duplication-rich human chromosome 16.

Nature

432

988-994

2004

571843

Loftus B.J.,Kim U.-J.,Sneddon V.P.,Kalush F.,Brandon R.,Fuhrmann J.,Mason T.,Crosby M.L.,Barnstead M.,Cronin L.,Mays A.D.,Cao Y.,Xu R.X.,Kang H.-L.,Mitchell S.,Eichler E.E.,Harris P.C.,Venter J.C.,Adams M.D.

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

Genomics

60

295-308

1999

571844

Leier I.,Jedlitschky G.,Buchholz U.,Cole S.P.,Deeley R.G.,Keppler D.

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

J. Biol. Chem.

269

27807-27810

1994

571845

Hipfner D.R.,Almquist K.C.,Leslie E.M.,Gerlach J.H.,Grant C.E.,Deeley R.G.,Cole S.P.C.

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

J. Biol. Chem.

272

23623-23630

1997

571846

Kast C.,Gros P.

Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence.

J. Biol. Chem.

272

26479-26487

1997

571847

Stride B.D.,Grant C.E.,Loe D.W.,Hipfner D.R.,Cole S.P.C.,Deeley R.G.

Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells.

Mol. Pharmacol.

52

344-353

1997

571848

Kast C.,Gros P.

Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein.

Biochemistry

37

2305-2313

1998

571849

Sjoelinder M.,Tornhamre S.,Claesson H.-E.,Hydman J.,Lindgren J.A.

Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.

J. Lipid Res.

40

439-446

1999

571850

Robbiani D.F.,Finch R.A.,Jaeger D.,Muller W.A.,Sartorelli A.C.,Randolph G.J.

The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes.

Cell

103

757-768

2000

571851

Cui L.,Hou Y.-X.,Riordan J.R.,Chang X.-B.

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation.

Arch. Biochem. Biophys.

392

153-161

2001

571852

Ito K.,Olsen S.L.,Qiu W.,Deeley R.G.,Cole S.P.C.

Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.

J. Biol. Chem.

276

15616-15624

2001

571853

Zhang D.-W.,Cole S.P.C.,Deeley R.G.

Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines.

J. Biol. Chem.

276

13231-13239

2001

571854

Situ D.,Haimeur A.,Conseil G.,Sparks K.E.,Zhang D.-W.,Deeley R.G.,Cole S.P.C.

Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter.

J. Biol. Chem.

279

38871-38880

2004

571855

Zhang D.-W.,Nunoya K.,Vasa M.,Gu H.-M.,Theis A.,Cole S.P.C.,Deeley R.G.

Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1.

Biochemistry

43

9413-9425

2004

571856

Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell

127

635-648

2006

571857

Conseil G.,Deeley R.G.,Cole S.P.

Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1).

J. Biol. Chem.

281

43-50

2006

571858

Mitra P.,Oskeritzian C.A.,Payne S.G.,Beaven M.A.,Milstien S.,Spiegel S.

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.

Proc. Natl. Acad. Sci. U.S.A.

103

16394-16399

2006

571859

Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Mol. Cell

31

438-448

2008

571860

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

571861

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

571862

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

571863

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

571864

Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci. Signal.

4

0-0

2011

571865

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

571866

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

571867

Ramaen O.,Leulliot N.,Sizun C.,Ulryck N.,Pamlard O.,Lallemand J.-Y.,Tilbeurgh H.,Jacquet E.

Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site.

J. Mol. Biol.

359

940-949

2006

571868

Le Saux O.,Urban Z.,Tschuch C.,Csiszar K.,Bacchelli B.,Quaglino D.,Pasquali-Ronchetti I.,Pope F.M.,Richards A.,Terry S.,Bercovitch L.,de Paepe A.,Boyd C.D.

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.

Nat. Genet.

25

223-227

2000

571869

Ringpfeil F.,Lebwohl M.G.,Christiano A.M.,Uitto J.

Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.

Proc. Natl. Acad. Sci. U.S.A.

97

6001-6006

2000

571870

Conrad S.,Kauffmann H.-M.,Ito K.,Deeley R.G.,Cole S.P.C.,Schrenk D.

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

J. Hum. Genet.

46

656-663

2001

571871

Perdu J.,Germain D.P.

Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum.

Hum. Mutat.

17

74-75

2001

571872

Ito S.,Ieiri I.,Tanabe M.,Suzuki A.,Higuchi S.,Otsubo K.

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

Pharmacogenetics

11

175-184

2001

571873

Ley T.J.,Mardis E.R.,Ding L.,Fulton B.,McLellan M.D.,Chen K.,Dooling D.,Dunford-Shore B.H.,McGrath S.,Hickenbotham M.,Cook L.,Abbott R.,Larson D.E.,Koboldt D.C.,Pohl C.,Smith S.,Hawkins A.,Abbott S.,Locke D.,Hillier L.W.,Miner T.,Fulton L.,Magrini V.,Wylie T.,Glasscock J.,Conyers J.,Sander N.,Shi X.,Osborne J.R.,Minx P.,Gordon D.,Chinwalla A.,Zhao Y.,Ries R.E.,Payton J.E.,Westervelt P.,Tomasson M.H.,Watson M.,Baty J.,Ivanovich J.,Heath S.,Shannon W.D.,Nagarajan R.,Walter M.J.,Link D.C.,Graubert T.A.,DiPersio J.F.,Wilson R.K.

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

Nature

456

66-72

2008

571874

Li M.,Mei L.,He C.,Chen H.,Cai X.,Liu Y.,Tian R.,Tian Q.,Song J.,Jiang L.,Liu C.,Wu H.,Li T.,Liu J.,Li X.,Yi Y.,Yan D.,Blanton S.H.,Hu Z.,Liu X.,Li J.,Ling J.,Feng Y.

Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis.

Genet. Med.

21

2744-2754

2019