Sequence of ERBB4_HUMAN
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
60 GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
120 LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
180 NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
240 PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
300 SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
360 KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
420 VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
480 INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
540 GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
600 NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG
660 LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR
720 VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL
780 VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV
840 HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
900 SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID
960 ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE
1020 EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP
1080 YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS
1140 PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED
1200 EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ
1260 EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
541128
Plowman G.D.,Culouscou J.-M.,Whitney G.S.,Green J.M.,Carlton G.W.,Foy L.,Neubauer M.G.,Shoyab M.
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
Proc. Natl. Acad. Sci. U.S.A.
90
1746-1750
1993
541129
Elenius K.,Corfas G.,Paul S.,Choi C.J.,Rio C.,Plowman G.D.,Klagsbrun M.
A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.
J. Biol. Chem.
272
26761-26768
1997
541130
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
541132
Culouscou J.-M.,Plowman G.D.,Carlton G.W.,Green J.M.,Shoyab M.
Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.
J. Biol. Chem.
268
18407-18410
1993
541133
Plowman G.D.,Green J.M.,Culouscou J.M.,Carlton G.W.,Rothwell V.M.,Buckley S.
Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.
Nature
366
473-475
1993
541134
Cohen B.D.,Green J.M.,Foy L.,Fell H.P.
HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.
J. Biol. Chem.
271
4813-4818
1996
541135
Riese D.J. II,Bermingham Y.,van Raaij T.M.,Buckley S.,Plowman G.D.,Stern D.F.
Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.
Oncogene
12
345-353
1996
541136
Elenius K.,Paul S.,Allison G.,Sun J.,Klagsbrun M.
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.
EMBO J.
16
1268-1278
1997
541137
Carraway K.L. III,Weber J.L.,Unger M.J.,Ledesma J.,Yu N.,Gassmann M.,Lai C.
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
Nature
387
512-516
1997
541138
Komurasaki T.,Toyoda H.,Uchida D.,Morimoto S.
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Oncogene
15
2841-2848
1997
541139
Zhang D.,Sliwkowski M.X.,Mark M.,Frantz G.,Akita R.,Sun Y.,Hillan K.,Crowley C.,Brush J.,Godowski P.J.
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.
Proc. Natl. Acad. Sci. U.S.A.
94
9562-9567
1997
541140
Fiddes R.J.,Campbell D.H.,Janes P.W.,Sivertsen S.P.,Sasaki H.,Wallasch C.,Daly R.J.
Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
J. Biol. Chem.
273
7717-7724
1998
541141
Olayioye M.A.,Beuvink I.,Horsch K.,Daly J.M.,Hynes N.E.
ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.
J. Biol. Chem.
274
17209-17218
1999
541142
Elenius K.,Choi C.J.,Paul S.,Santiestevan E.,Nishi E.,Klagsbrun M.
Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.
Oncogene
18
2607-2615
1999
541143
Harari D.,Tzahar E.,Romano J.,Shelly M.,Pierce J.H.,Andrews G.C.,Yarden Y.
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.
Oncogene
18
2681-2689
1999
541144
Kainulainen V.,Sundvall M.,Maatta J.A.,Santiestevan E.,Klagsbrun M.,Elenius K.
A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis.
J. Biol. Chem.
275
8641-8649
2000
541145
Rio C.,Buxbaum J.D.,Peschon J.J.,Corfas G.
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
J. Biol. Chem.
275
10379-10387
2000
541146
Sweeney C.,Lai C.,Riese D.J. II,Diamonti A.J.,Cantley L.C.,Carraway K.L. III
Ligand discrimination in signaling through an ErbB4 receptor homodimer.
J. Biol. Chem.
275
19803-19807
2000
541147
Garcia R.A.,Vasudevan K.,Buonanno A.
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.
Proc. Natl. Acad. Sci. U.S.A.
97
3596-3601
2000
541148
Egeblad M.,Mortensen O.H.,van Kempen L.C.,Jaattela M.
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Biochem. Biophys. Res. Commun.
281
25-31
2001
541149
Sartor C.I.,Zhou H.,Kozlowska E.,Guttridge K.,Kawata E.,Caskey L.,Harrelson J.,Hynes N.,Ethier S.,Calvo B.,Earp H.S. III
Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.
Mol. Cell. Biol.
21
4265-4275
2001
541150
Komuro A.,Nagai M.,Navin N.E.,Sudol M.
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.
J. Biol. Chem.
278
33334-33341
2003
541151
Li Y.,Yu W.-H.,Ren J.,Chen W.,Huang L.,Kharbanda S.,Loda M.,Kufe D.
Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.
Mol. Cancer Res.
1
765-775
2003
541152
Williams C.C.,Allison J.G.,Vidal G.A.,Burow M.E.,Beckman B.S.,Marrero L.,Jones F.E.
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.
J. Cell Biol.
167
469-478
2004
541153
Aqeilan R.I.,Donati V.,Palamarchuk A.,Trapasso F.,Kaou M.,Pekarsky Y.,Sudol M.,Croce C.M.
WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.
Cancer Res.
65
6764-6772
2005
541154
Vidal G.A.,Naresh A.,Marrero L.,Jones F.E.
Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities.
J. Biol. Chem.
280
19777-19783
2005
541155
Naresh A.,Long W.,Vidal G.A.,Wimley W.C.,Marrero L.,Sartor C.I.,Tovey S.,Cooke T.G.,Bartlett J.M.,Jones F.E.
The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells.
Cancer Res.
66
6412-6420
2006
541156
Linggi B.,Carpenter G.
ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.
J. Biol. Chem.
281
25373-25380
2006
541157
Maatta J.A.,Sundvall M.,Junttila T.T.,Peri L.,Laine V.J.,Isola J.,Egeblad M.,Elenius K.
Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.
Mol. Biol. Cell
17
67-79
2006
541158
Muraoka-Cook R.S.,Sandahl M.,Husted C.,Hunter D.,Miraglia L.,Feng S.M.,Elenius K.,Earp H.S. III
The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.
Mol. Biol. Cell
17
4118-4129
2006
541159
Pitfield S.E.,Bryant I.,Penington D.J.,Park G.,Riese D.J. II
Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.
Oncol. Res.
16
179-193
2006
541160
Strunk K.E.,Husted C.,Miraglia L.C.,Sandahl M.,Rearick W.A.,Hunter D.M.,Earp H.S. III,Muraoka-Cook R.S.
HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4.
Cancer Res.
67
6582-6590
2007
541161
Li Z.,Mei Y.,Liu X.,Zhou M.
Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.
Cell. Signal.
19
466-471
2007
541162
Sundvall M.,Peri L.,Maatta J.A.,Tvorogov D.,Paatero I.,Savisalo M.,Silvennoinen O.,Yarden Y.,Elenius K.
Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains.
Oncogene
26
6905-6914
2007
541163
Kaushansky A.,Gordus A.,Budnik B.A.,Lane W.S.,Rush J.,MacBeath G.
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
Chem. Biol.
15
808-817
2008
541164
Zeng F.,Xu J.,Harris R.C.
Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.
FASEB J.
23
1935-1945
2009
541165
Tvorogov D.,Sundvall M.,Kurppa K.,Hollmen M.,Repo S.,Johnson M.S.,Elenius K.
Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.
J. Biol. Chem.
284
5582-5591
2009
541166
Li Y.,Zhou Z.,Alimandi M.,Chen C.
WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.
Oncogene
28
2948-2958
2009
541167
Gilmore-Hebert M.,Ramabhadran R.,Stern D.F.
Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.
Mol. Cancer Res.
8
1388-1398
2010
541168
Carrasco-Garcia E.,Saceda M.,Grasso S.,Rocamora-Reverte L.,Conde M.,Gomez-Martinez A.,Garcia-Morales P.,Ferragut J.A.,Martinez-Lacaci I.
Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
Exp. Cell Res.
317
1476-1489
2011
541169
Jones F.E.,Golding J.P.,Gassmann M.
ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities.
Cell Cycle
2
555-559
2003
541170
Zaczek A.,Brandt B.,Bielawski K.P.
The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches.
Histol. Histopathol.
20
1005-1015
2005
541171
Muraoka-Cook R.S.,Feng S.M.,Strunk K.E.,Earp H.S. III
ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.
J. Mammary Gland Biol. Neoplasia
13
235-246
2008
541172
Jones F.E.
HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer.
J. Mammary Gland Biol. Neoplasia
13
247-258
2008
541173
Sundvall M.,Iljin K.,Kilpinen S.,Sara H.,Kallioniemi O.P.,Elenius K.
Role of ErbB4 in breast cancer.
J. Mammary Gland Biol. Neoplasia
13
259-268
2008
541174
Xu Y.,Li X.,Liu X.,Zhou M.
Neuregulin-1/ErbB signaling and chronic heart failure.
Adv. Pharmacol.
59
31-51
2010
541175
Veikkolainen V.,Vaparanta K.,Halkilahti K.,Iljin K.,Sundvall M.,Elenius K.
Function of ERBB4 is determined by alternative splicing.
Cell Cycle
10
2647-2657
2011
541176
Bouyain S.,Longo P.A.,Li S.,Ferguson K.M.,Leahy D.J.
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.
Proc. Natl. Acad. Sci. U.S.A.
102
15024-15029
2005
541177
Wood E.R.,Shewchuk L.M.,Ellis B.,Brignola P.,Brashear R.L.,Caferro T.R.,Dickerson S.H.,Dickson H.D.,Donaldson K.H.,Gaul M.,Griffin R.J.,Hassell A.M.,Keith B.,Mullin R.,Petrov K.G.,Reno M.J.,Rusnak D.W.,Tadepalli S.M.,Ulrich J.C.,Wagner C.D.,Vanderwall D.E.,Waterson A.G.,Williams J.D.,White W.L.,Uehling D.E.
6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Proc. Natl. Acad. Sci. U.S.A.
105
2773-2778
2008
541178
Qiu C.,Tarrant M.K.,Choi S.H.,Sathyamurthy A.,Bose R.,Banjade S.,Pal A.,Bornmann W.G.,Lemmon M.A.,Cole P.A.,Leahy D.J.
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Structure
16
460-467
2008
541179
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
541180
Takahashi Y.,Fukuda Y.,Yoshimura J.,Toyoda A.,Kurppa K.,Moritoyo H.,Belzil V.V.,Dion P.A.,Higasa K.,Doi K.,Ishiura H.,Mitsui J.,Date H.,Ahsan B.,Matsukawa T.,Ichikawa Y.,Moritoyo T.,Ikoma M.,Hashimoto T.,Kimura F.,Murayama S.,Onodera O.,Nishizawa M.,Yoshida M.,Atsuta N.,Sobue G.,Fifita J.A.,Williams K.L.,Blair I.P.,Nicholson G.A.,Gonzalez-Perez P.,Brown R.H. Jr.,Nomoto M.,Elenius K.,Rouleau G.A.,Fujiyama A.,Morishita S.,Goto J.,Tsuji S.,Nakamura R.,Watanabe H.,Izumi Y.,Kaji R.,Morita M.,Ogaki K.,Taniguchi A.,Aiba I.,Mizoguchi K.,Okamoto K.,Hasegawa K.,Aoki M.,Kawata A.,Nakano I.,Abe K.,Oda M.,Konagaya M.,Imai T.,Nakagawa M.,Fujita T.,Sasaki H.,Nishizawa M.
ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.
Am. J. Hum. Genet.
93
900-905
2013
