Sequence of DHB4_RAT
EC Number:4.2.1.107
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
P97852
Rattus norvegicus
735
79428
Reaction
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
Other sequences found for EC No. 4.2.1.107
General information:
Sequence
0 MASPLRFDGR VVLVTGAGGG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSSAADKVVE
60 EIRRRGGKAV ANYDSVEAGE KLVKTALDTF GRIDVVVNNA GILRDRSFSR ISDEDWDIIQ
120 RVHLRGSFQV TRAAWDHMKK QNYGRIIMTA SASGIYGNFG QANYSAAKLG LLGLANTLVI
180 EGRKNNIHCN TIAPNAGSRM TETVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG
240 AGWIGKLRWE RTLGAIVRKR NQPMTPEAVR DNWVKICDFS NASKPKSIQE STGGIIEVLH
300 KIDSEGISQN HTGQVASADA SGFAGVVGHK LPSFSSSYTE LQCIMYALGV GASVKNPKDL
360 KFVYEGSADF SCLPTFGVIV AQKSLMSGGL AEVPGLSINF AKVLHGEQYL ELYKPLPRSG
420 ELKCEAVIAD ILDKGSGIVI VMDVYSYSGK ELICYNQFSV FVVGSGGFGG KRTSEKLKAA
480 VAVPSRPPDA VLRDTTSLNQ AALYRLSGDS NPLHIDPSFA SIAGFEKPIL HGLCTFGFSA
540 RHVLQQFADN DVSRFKAIKV RFAKPVYPGQ TLQTEMWKEG NRIHFQTKVQ ETGDIVISNA
600 YVDLVPTSGV SAQTPSEGGA LQSALVFGEI GRRLKDVGRE VVKKVNAVFE WHITKNGNVA
660 AKWTIDLKNG SGEVYQGPAK GSADTTITIS DEDFMEVVLG KLNPQNAFFS GRLKARGNIM
720 LSQKLQMILK DYAKL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
535405
Dieuaide-Noubhani M.,Novikov D.,Baumgart E.,Vanhooren J.C.T.,Fransen M.,Goethals M.,Vandekerckhove J.,Van Veldhoven P.P.,Mannaerts G.P.
Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins.
Eur. J. Biochem.
240
660-666
1996
535407
Corton J.C.,Bocos C.,Moreno E.S.,Merritt A.,Marsman D.S.,Sausen P.J.,Cattley R.C.,Gustafsson J.-A.
Rat 17 beta-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene.
Mol. Pharmacol.
50
1157-1166
1996
535408
Qin Y.M.,Poutanen M.H.,Helander H.M.,Kvist A.P.,Siivari K.M.,Schmitz W.,Conzelmann E.,Hellman U.,Hiltunen J.K.
Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization.
Biochem. J.
321
21-28
1997
535409
Dieuaide-Noubhani M.,Novikov D.,Vandekerckhove J.,Veldhoven P.P.,Mannaerts G.P.
Identification and characterization of the 2-enoyl-CoA hydratases involved in peroxisomal beta-oxidation in rat liver.
Biochem. J.
321
253-259
1997
535410
Haapalainen A.M.,Koski M.K.,Qin Y.-M.,Hiltunen J.K.,Glumoff T.
Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.
Structure
11
87-97
2003
