Sequence of COP1_ARATH
EC Number:2.3.2.27
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.27
General information:
Sequence
0 MEEISTDPVV PAVKPDPRTS SVGEGANRHE NDDGGSGGSE IGAPDLDKDL LCPICMQIIK
60 DAFLTACGHS FCYMCIITHL RNKSDCPCCS QHLTNNQLYP NFLLDKLLKK TSARHVSKTA
120 SPLDQFREAL QRGCDVSIKE VDNLLTLLAE RKRKMEQEEA ERNMQILLDF LHCLRKQKVD
180 ELNEVQTDLQ YIKEDINAVE RHRIDLYRAR DRYSVKLRML GDDPSTRNAW PHEKNQIGFN
240 SNSLSIRGGN FVGNYQNKKV EGKAQGSSHG LPKKDALSGS DSQSLNQSTV SMARKKRIHA
300 QFNDLQECYL QKRRQLADQP NSKQENDKSV VRREGYSNGL ADFQSVLTTF TRYSRLRVIA
360 EIRHGDIFHS ANIVSSIEFD RDDELFATAG VSRCIKVFDF SSVVNEPADM QCPIVEMSTR
420 SKLSCLSWNK HEKNHIASSD YEGIVTVWDV TTRQSLMEYE EHEKRAWSVD FSRTEPSMLV
480 SGSDDCKVKV WCTRQEASVI NIDMKANICC VKYNPGSSNY IAVGSADHHI HYYDLRNISQ
540 PLHVFSGHKK AVSYVKFLSN NELASASTDS TLRLWDVKDN LPVRTFRGHT NEKNFVGLTV
600 NSEYLACGSE TNEVYVYHKE ITRPVTSHRF GSPDMDDAEE EAGSYFISAV CWKSDSPTML
660 TANSQGTIKV LVLAA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
529103
Deng X.-W.,Matsui M.,Wei N.,Wagner D.,Chu A.M.,Feldmann K.A.,Quail P.H.
COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain.
Cell
71
791-801
1992
529104
Lin X.,Kaul S.,Rounsley S.D.,Shea T.P.,Benito M.-I.,Town C.D.,Fujii C.Y.,Mason T.M.,Bowman C.L.,Barnstead M.E.,Feldblyum T.V.,Buell C.R.,Ketchum K.A.,Lee J.J.,Ronning C.M.,Koo H.L.,Moffat K.S.,Cronin L.A.,Shen M.,Pai G.,Van Aken S.,Umayam L.,Tallon L.J.,Gill J.E.,Adams M.D.,Carrera A.J.,Creasy T.H.,Goodman H.M.,Somerville C.R.,Copenhaver G.P.,Preuss D.,Nierman W.C.,White O.,Eisen J.A.,Salzberg S.L.,Fraser C.M.,Venter J.C.
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.
Nature
402
761-768
1999
529105
Cheng C.Y.,Krishnakumar V.,Chan A.P.,Thibaud-Nissen F.,Schobel S.,Town C.D.
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
Plant J.
89
789-804
2017
529107
Simpson C.G.,Mcquade C.,Lyon J.,Brown J.W.S.
Characterisation of exon skipping mutants of the COP1 gene from Arabidopsis.
Plant J.
15
125-131
1998
529108
McNellis T.W.,von Arnim A.G.,Araki T.,Komeda Y.,Misera S.,Deng X.-W.
Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains.
Plant Cell
6
487-500
1994
529109
Matsui M.,Stoop C.D.,von Arnim A.G.,Wei N.,Deng X.-W.
Arabidopsis COP1 protein specifically interacts in vitro with a cytoskeleton-associated protein, CIP1.
Proc. Natl. Acad. Sci. U.S.A.
92
4239-4243
1995
529110
Stacey M.G.,von Arnim A.G.
A novel motif mediates the targeting of the Arabidopsis COP1 protein to subnuclear foci.
J. Biol. Chem.
274
27231-27236
1999
529111
Torii K.U.,McNellis T.W.,Deng X.-W.
Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development.
EMBO J.
17
5577-5587
1998
529112
Yamamoto Y.Y.,Matsui M.,Ang L.-H.,Deng X.-W.
Role of a COP1 interactive protein in mediating light-regulated gene expression in arabidopsis.
Plant Cell
10
1083-1094
1998
529113
Torii K.U.,Stoop-Myer C.D.,Okamoto H.,Coleman J.E.,Matsui M.,Deng X.-W.
The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein.
J. Biol. Chem.
274
27674-27681
1999
529114
Stacey M.G.,Hicks S.N.,von Arnim A.G.
Discrete domains mediate the light-responsive nuclear and cytoplasmic localization of Arabidopsis COP1.
Plant Cell
11
349-364
1999
529115
Hoecker U.,Quail P.H.
The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis.
J. Biol. Chem.
276
38173-38178
2001
529116
Holm M.,Hardtke C.S.,Gaudet R.,Deng X.-W.
Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1.
EMBO J.
20
118-127
2001
529117
Osterlund M.T.,Hardtke C.S.,Wei N.,Deng X.-W.
Targeted destabilization of HY5 during light-regulated development of Arabidopsis.
Nature
405
462-466
2000
529118
Holm M.,Ma L.-G.,Qu L.-J.,Deng X.-W.
Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis.
Genes Dev.
16
1247-1259
2002
529119
Shin B.,Choi G.,Yi H.,Yang S.,Cho I.,Kim J.,Lee S.,Paek N.-C.,Kim J.-H.,Song P.S.,Choi G.
AtMYB21, a gene encoding a flower-specific transcription factor, is regulated by COP1.
Plant J.
30
23-32
2002
529120
Saijo Y.,Sullivan J.A.,Wang H.,Yang J.,Shen Y.,Rubio V.,Ma L.,Hoecker U.,Deng X.W.
The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity.
Genes Dev.
17
2642-2647
2003
529121
Laubinger S.,Hoecker U.
The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light.
Plant J.
35
373-385
2003
529122
Seo H.S.,Yang J.-Y.,Ishikawa M.,Bolle C.,Ballesteros M.L.,Chua N.-H.
LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1.
Nature
423
995-999
2003
529123
Laubinger S.,Fittinghoff K.,Hoecker U.
The SPA quartet: a family of WD-repeat proteins with a central role in suppression of photomorphogenesis in Arabidopsis.
Plant Cell
16
2293-2306
2004
529124
Yanagawa Y.,Sullivan J.A.,Komatsu S.,Gusmaroli G.,Suzuki G.,Yin J.,Ishibashi T.,Saijo Y.,Rubio V.,Kimura S.,Wang J.,Deng X.-W.
Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes.
Genes Dev.
18
2172-2181
2004
529125
Saijo Y.,Zhu D.,Li J.,Rubio V.,Zhou Z.,Shen Y.,Hoecker U.,Wang H.,Deng X.W.
Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling.
Mol. Cell
31
607-613
2008
529126
Lee J.H.,Terzaghi W.,Gusmaroli G.,Charron J.B.,Yoon H.J.,Chen H.,He Y.J.,Xiong Y.,Deng X.W.
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.
Plant Cell
20
152-167
2008
529127
Favory J.J.,Stec A.,Gruber H.,Rizzini L.,Oravecz A.,Funk M.,Albert A.,Cloix C.,Jenkins G.I.,Oakeley E.J.,Seidlitz H.K.,Nagy F.,Ulm R.
Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis.
EMBO J.
28
591-601
2009
529128
Jeong R.-D.,Chandra-Shekara A.C.,Barman S.R.,Navarre D.,Klessig D.F.,Kachroo A.,Kachroo P.
Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase.
Proc. Natl. Acad. Sci. U.S.A.
107
13538-13543
2010
529129
Rizzini L.,Favory J.J.,Cloix C.,Faggionato D.,O'Hara A.,Kaiserli E.,Baumeister R.,Schaefer E.,Nagy F.,Jenkins G.I.,Ulm R.
Perception of UV-B by the Arabidopsis UVR8 protein.
Science
332
103-106
2011
529130
Srivastava A.K.,Senapati D.,Srivastava A.,Chakraborty M.,Gangappa S.N.,Chattopadhyay S.
SHORT HYPOCOTYL IN WHITE LIGHT1 interacts with ELONGATED HYPOCOTYL5 (HY5) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and promotes COP1-mediated degradation of HY5 during Arabidopsis seedling development.
Plant Physiol.
169
2922-2934
2015
529131
Xu D.,Lin F.,Jiang Y.,Ling J.,Hettiarachchi C.,Tellgren-Roth C.,Holm M.,Wei N.,Deng X.W.
Arabidopsis COP1 SUPPRESSOR 2 represses COP1 E3 ubiquitin ligase activity through their coiled-coil domains association.
PLoS Genet.
11
0-0
2015
529132
Kim S.-H.,Kim H.,Chung S.,Lee J.-H.
DHU1 negatively regulates UV-B signaling via its direct interaction with COP1 and RUP1.
Biochem. Biophys. Res. Commun.
491
285-290
2017
529133
Uljon S.,Xu X.,Durzynska I.,Stein S.,Adelmant G.,Marto J.A.,Pear W.S.,Blacklow S.C.
Structural basis for substrate selectivity of the E3 ligase COP1.
Structure
24
687-696
2016
