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Sequence of CHD1_HUMAN

EC Number:3.6.4.12

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3.6.4.12
DNA helicase
O14646
Homo sapiens
1710
196688
Swiss-Prot
Reaction
Other sequences found for EC No. 3.6.4.12

General information:

Sequence
show sequence in fasta format
   0 MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS DSDSGSESGS
  60 QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA ILKKQQQQQQ QQQHQASSNS
 120 GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ MSGSGSPSQS GSDSESEEER EKSSCDETES
 180 DYEPKNKVKS RKPQNRSKSK NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV
 240 SYKEDEEMKT DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD
 300 GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD NYKKKDQETK
 360 RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ KSAAGYPDYY CKWQGLPYSE
 420 CSWEDGALIS KKFQACIDEY FSRNQSKTTP FKDCKVLKQR PRFVALKKQP SYIGGHEGLE
 480 LRDYQLNGLN WLAHSWCKGN SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS
 540 TLTSWQREIQ TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK
 600 AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL KELWSLLHFI
 660 MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK DVEKSLPAKV EQILRMEMSA
 720 LQKQYYKWIL TRNYKALSKG SKGSTSGFLN IMMELKKCCN HCYLIKPPDN NEFYNKQEAL
 780 QHLIRSSGKL ILLDKLLIRL RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG
 840 ELRKQALDHF NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR
 900 IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT GSAPSSSTPF
 960 NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE THENEPGPLT VGDELLSQFK
1020 VANFSNMDED DIELEPERNS KNWEEIIPED QRRRLEEEER QKELEEIYML PRMRNCAKQI
1080 SFNGSEGRRS RSRRYSGSDS DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK
1140 FGGPLERLDA IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP
1200 TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD IDWGKEDDSN
1260 LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK QLQTRADYLI KLLSRDLAKK
1320 EALSGAGSSK RRKARAKKNK AMKSIKVKEE IKSDSSPLPS EKSDEDDDKL SESKSDGRER
1380 SKKSSVSDAP VHITASGEPV PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE
1440 REQLEHTRQC LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA
1500 IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL TQYHDHHKDR
1560 HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD REKHRKLDDH RSRDHRSNLE
1620 GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD
1680 QRSPYGSRSP FEHSVEHKST PEHTWSSRKT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
526199
Woodage T.,Basrai M.A.,Baxevanis A.D.,Hieter P.,Collins F.S.
Characterization of the CHD family of proteins.
Proc. Natl. Acad. Sci. U.S.A.
94
11472-11477
1997
9326634
526200
Schmutz J.,Martin J.,Terry A.,Couronne O.,Grimwood J.,Lowry S.,Gordon L.A.,Scott D.,Xie G.,Huang W.,Hellsten U.,Tran-Gyamfi M.,She X.,Prabhakar S.,Aerts A.,Altherr M.,Bajorek E.,Black S.,Branscomb E.,Caoile C.,Challacombe J.F.,Chan Y.M.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Lopez F.,Lou Y.,Martinez D.,Medina C.,Morgan J.,Nandkeshwar R.,Noonan J.P.,Pitluck S.,Pollard M.,Predki P.,Priest J.,Ramirez L.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wheeler J.,Wu K.,Yang J.,Dickson M.,Cheng J.-F.,Eichler E.E.,Olsen A.,Pennacchio L.A.,Rokhsar D.S.,Richardson P.,Lucas S.M.,Myers R.M.,Rubin E.M.
The DNA sequence and comparative analysis of human chromosome 5.
Nature
431
268-274
2004
15372022
526201
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
526202
Sims R.J. III,Chen C.-F.,Santos-Rosa H.,Kouzarides T.,Patel S.S.,Reinberg D.
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.
J. Biol. Chem.
280
41789-41792
2005
16263726
526203
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
17081983
526204
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
16964243
526205
Flanagan J.F.,Blus B.J.,Kim D.,Clines K.L.,Rastinejad F.,Khorasanizadeh S.
Molecular implications of evolutionary differences in CHD double chromodomains.
J. Mol. Biol.
369
334-342
2007
17433364
526206
Sims R.J. III,Millhouse S.,Chen C.-F.,Lewis B.A.,Erdjument-Bromage H.,Tempst P.,Manley J.L.,Reinberg D.
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
Mol. Cell
28
665-676
2007
18042460
526207
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
18691976
526208
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
18669648
526209
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
19690332
526210
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
20068231
526211
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
21269460
526212
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
21406692
526213
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
23186163
526214
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
24275569
526215
Pilarowski G.O.,Vernon H.J.,Applegate C.D.,Boukas L.,Cho M.T.,Gurnett C.A.,Benke P.J.,Beaver E.,Heeley J.M.,Medne L.,Krantz I.D.,Azage M.,Niyazov D.,Henderson L.B.,Wentzensen I.M.,Baskin B.,Sacoto M.J.G.,Bowman G.D.,Bjornsson H.T.
Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability.
J. Med. Genet.
55
561-566
2018
28866611
526216
Flanagan J.F.,Mi L.-Z.,Chruszcz M.,Cymborowski M.,Clines K.L.,Kim Y.,Minor W.,Rastinejad F.,Khorasanizadeh S.
Double chromodomains cooperate to recognize the methylated histone H3 tail.
Nature
438
1181-1185
2005
16372014