Sequence of CATB_BOVIN
EC Number:3.4.22.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
Other sequences found for EC No. 3.4.22.1
General information:
Sequence
0 MWRLLATLSC LLVLTSARSS LYFPPLSDEL VNFVNKQNTT WKAGHNFYNV DLSYVKKLCG
60 AILGGPKLPQ RDAFAADVVL PESFDAREQW PNCPTIKEIR DQGSCGSCWA FGAVEAISDR
120 ICIHSNGRVN VEVSAEDMLT CCGGECGDGC NGGFPSGAWN FWTKKGLVSG GLYNSHVGCR
180 PYSIPPCEHH VNGSRPPCTG EGDTPKCSKT CEPGYSPSYK EDKHFGCSSY SVANNEKEIM
240 AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV SGEIMGGHAI RILGWGVENG TPYWLVGNSW
300 NTDWGDNGFF KILRGQDHCG IESEIVAGMP CTHQY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
523275
Bechet D.M.,Ferrara M.J.,Mordier S.B.,Roux M.-P.,Deval C.,Obled A.
Expression of lysosomal cathepsin B during calf myoblast-myotube differentiation. Characterization of a cDNA encoding bovine cathepsin B.
J. Biol. Chem.
266
14104-14112
1991
523276
Mordier S.,Bechet D.,Roux M.-P.,Obled A.,Ferrara M.
Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region.
Biochim. Biophys. Acta
1174
305-311
1993
523278
Meloun B.,Baudys M.,Pohl J.,Pavlik M.,Kostka V.
Amino acid sequence of bovine spleen cathepsin B.
J. Biol. Chem.
263
9087-9093
1988
523280
Pohl J.,Baudys M.,Tomasek V.,Kostka V.
Identification of the active site cysteine and of the disulfide bonds in the N-terminal part of the molecule of bovine spleen cathepsin B.
FEBS Lett.
142
23-26
1982
523281
Baudys M.,Meloun B.,Pohl J.,Kostka V.
Identification of the second (buried) cysteine residue and of the C-terminal disulfide bridge of bovine spleen cathepsin B.
Biol. Chem. Hoppe-Seyler
369
169-174
1988
523282
Baudys M.,Meloun B.,Gan-Erdene T.,Pohl J.,Kostka V.
Disulfide bridges of bovine spleen cathepsin B.
Biol. Chem. Hoppe-Seyler
371
485-491
1990
523283
Yamamoto A.,Tomoo K.,Hara T.,Murata M.,Kitamura K.,Ishida T.
Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex.
J. Biochem.
127
635-643
2000
