EC Number |
Protein Variants |
Reference |
---|
6.4.1.3 | A431C |
kcat (propionyl-CoA) decreased compared to wild-type, Km (propionyl-CoA) increased compared to wild-type. kcat (acetyl-CoA) increased compared to wild-type, Km (propionyl-CoA) similar to wild-type |
726557 |
6.4.1.3 | A431D |
mutant enzyme shows no activity |
726557 |
6.4.1.3 | A431I |
kcat (propionyl-CoA) decreased compared to wild-type, Km (propionyl-CoA) increased compared to wild-type. kcat (acetyl-CoA) increased compared to wild-type, Km (propionyl-CoA) similar to wild-type |
726557 |
6.4.1.3 | A431L |
mutant enzyme shows no activity |
726557 |
6.4.1.3 | A487V |
no effect on activity |
652691 |
6.4.1.3 | A497V |
beta subunit, no effect on subunit interactions and activity |
653247 |
6.4.1.3 | A497V |
polymorphism, 30% higher specific activity than wild-type enzyme |
662392 |
6.4.1.3 | A497V |
significantly increased activity |
651459 |
6.4.1.3 | A513_R514insP |
insertion between residues 513 and 514 of the beta subunit, leads to partial degradation of the subunit, strongly reduced activity |
653246 |
6.4.1.3 | A513_R514insP |
insertion, severe degradation of the subunit |
651459 |