EC Number   |
Protein Variants |
Reference |
|---|
    6.3.4.21 | D19A |
activity completely abolished |
721763 |
| 6.3.4.21 | D288A |
about 10% of wild type activity |
721763 |
| 6.3.4.21 | G169A |
about 40% of wild type activity |
721763 |
| 6.3.4.21 | G209A |
about 20% of wild type activity |
721763 |
| 6.3.4.21 | G379A |
activity completely abolished |
721763 |
| 6.3.4.21 | H213A |
about 50% of wild type activity |
721763 |
| 6.3.4.21 | H213A |
mutant is unable to generate adenosine 5'-tetraphosphate |
744647 |
| 6.3.4.21 | N357A |
about 80% of wild type activity |
721763 |
| 6.3.4.21 | P21L |
mutation identified in a strain with early leaf sensescence, mutation causes the expression of the gene at the transcriptional level to decline by 40% in fully expanded leaves. Leaf nicotinate and nicotinamide contents are elevated, while NAD levels are reduced. Leaf tissue of P21L exhibits significant DNA fragmentation and H2O2 accumulation, along with up-regulation of genes associated with senescence. The mutant also shows reduced expression of SIR2-like genes SRT1 and SRT2 and increased acetylation of histone H3K9 |
746114 |
| 6.3.4.21 | R318A |
activity strictly dependent on the presence of ATP |
721763 |
