EC Number   |
Protein Variants |
Reference |
|---|
    5.3.99.4 | C441H |
no heme-binding ability, no activity |
662059 |
| 5.3.99.4 | DELTA-20-PGIS |
PGH2 presentation to the membrane-bound mutant has a 2 to 3fold delay compared to that of membrane-bound wild-type PGIS |
660808 |
| 5.3.99.4 | more |
fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, separated by a transmembrane domain of 10 or 22 residues. Expressed protein is able to convert arachidonic acid to prostaglandin G2, prostaglandin H2 and prostaglandin I2. Fusion protein may directly synthesize prostaglandin I2 from arachidonic acid with Km value of 0.0032 mM |
678166 |
| 5.3.99.4 | more |
specific transgenic expression of prostacyclin synthase in mouse kidney results in increased in urinary 6-keto-prostaglandin F1alpha. Transgenic mice demonstrate endotoxemia-related acute kidney injury with low doses of lipopolysaccharide, which do not alter wild-type glomerular filtration rate. They also show increase in renal cAMP content |
677494 |
| 5.3.99.4 | PGIS/TXAS(8-27) |
the first 20 membrane anchor residues of human PGIS are replaced by the corresponding membrane anchor region of human TXAS (thromboxane A2 synthase). Efficiency of the isomerization of PGH2 to PGI2 is slowed down with approximately 25, 65, and 85% at 30, 60, and 120 s reactions, compared to the wild-type PGIS, respectively |
660808 |
