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Results 1 - 10 of 15 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5A165K/N174L/T391Y site-directed mutagenesis, the mutant shows no activity towards L-Ala, L-Lys, or L-Arg -, 728587
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5more for D-lysine production, a two-step process for D-lysine production from L-lysine by the successive microbial racemization and asymmetric degradation with lysine racemase and decarboxylase is developed. L-lysine is rapidly racemized to give DL-lysine, and L-lysine is selectively catabolized to generate cadaverine by lysine decarboxylase. In order to obtain enantiopure D-lysine, chiral selective degradation of L-lysine from the reaction mixture of DL-lysine is necessary. Under optimal conditions, 750.7 mmol/l D-lysine is finally obtained from 1710 mmol/l L-lysine after 1 h of racemization reaction and 0.5 h of decarboxylation reaction. D-lysine yield can reach 48.8% with enantiomeric excess of 99% or more -, 747470
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5more in an attempt to limit extracellular Lyr (while retaining the catalytic activity), amino acids 1-36 are removed from the enzyme (LyrM37) and a C-terminal KDEL ER retention motif (LyrM37-KDEL) is added 748654
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5N174L site-directed mutagenesis, inactive mutant -, 728587
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5R173A site-directed mutagenesis, inactive mutant -, 728587
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5R173K site-directed mutagenesis, inactive mutant -, 728587
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5S394C site-directed mutagenesis, the mutant shows 1.5fold increased activity with L-arginine compared to the wild-type enzyme -, 728711
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5S394N site-directed mutagenesis, the mutant shows about 2.2fold increased activity with L-arginine compared to the wild-type enzyme -, 728711
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5S394T site-directed mutagenesis, the mutant shows 1.8fold increased activity with L-arginine compared to the wild-type enzyme -, 728711
Show all pathways known for 5.1.1.5Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.5S394Y site-directed mutagenesis, the mutant shows 2.1fold increased activity with L-arginine compared to the wild-type enzyme -, 728711
Results 1 - 10 of 15 > >>