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Results 1 - 10 of 26 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A site-directed mutagenesis -, 747506
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A site-directed mutagenesis, mutant enzyme activity analysis using an SP dinucleoside and an SP-containing oligonucleotide -, 748852
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A site-directed mutagenesis, the mutant shows a similar protein and substrate binding structure compared to the wild-type enzyme, but 2.5fold reduced repair activity -, 728401
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A site-directed mutagenesis, the mutant still shows catalytic turnover, but reduced activity, due to a replacement of the thiyl radical by a thermodynamically comparable glycyl radical16 in the catalytic cycle 727295
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A/S76C site-directed mutagenesis -, 747506
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140A/S76C site-directed mutagenesis, contrary to the C140A mutant, the double mutant repaires the DNA lesion without generating DNA adducts. Furthermore, in the crystal structure, the mutant S76C is shown to be at 4.1 A from the methylene bridge of SP which is a shorter distance than the one reported for the wild-type enzyme -, 748852
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140G site-directed mutagenesis, the mutant still shows catalytic turnover, but reduced activity, due to a replacement of the thiyl radical by a thermodynamically comparable glycyl radical16 in the catalytic cycle 727295
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140S site-directed mutagenesis, mutant enzyme activity analysis using an SP dinucleoside and an SP-containing oligonucleotide -, 748852
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C140S site-directed mutagenesis, the mutant shows a similar protein and substrate binding structure compared to the wild-type enzyme, but reduced repair activity -, 728401
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14C141A site-directed mutagenesis, mutant enzyme activity analysis using an SP dinucleoside and an SP-containing oligonucleotide -, 748852
Results 1 - 10 of 26 > >>