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EC Number
Protein Variants
Commentary
Reference
4.1.2.50
C27A
inactive
748175
4.1.2.50
C27A
significant decrease in catalytic activity
726593
4.1.2.50
D70N/H71A
the mutant shows greatly reduced activity compared to the wild type enzyme
748175
4.1.2.50
F55L
mutants shows 6-pyruvoyltetrahydropterin synthase activities comparable to the mammalian enzymes, with concomitant decrease in 6-carboxytetrahydropterin synthase activity
726593
4.1.2.50
H25A/D54N
inactive
748175
4.1.2.50
H25A/D54N/D70N/H71A
inactive
748175
4.1.2.50
W51M
mutants shows 6-pyruvoyltetrahydropterin synthase activities comparable to the mammalian enzymes, with concomitant decrease in 6-carboxytetrahydropterin synthase activity
726593
4.1.2.50
W51M/F55L
mutants shows 6-pyruvoyltetrahydropterin synthase activities comparable to the mammalian enzymes, with concomitant decrease in 6-carboxytetrahydropterin synthase activity
726593
Results
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