EC Number   |
Protein Variants |
Reference |
|---|
  3.9.1.2 | C14S |
mutation of auxiliary cysteine residue present in the active site, significant resuction in kcat value |
728854 |
| 3.9.1.2 | C7S |
structure in complex with phosphate shows the formation of a covalent phospho-Ser7 adduct indicating that the crystallized mutant mimics the phospho-enzyme intermediate of the dephosphorylation reaction |
729550 |
| 3.9.1.2 | C9A |
substrate-trapping mutant, retains binding affinity toward arginine-phosphorylated proteins but cannot hydrolyze the captured substrates. Mutant C9A stably binds to arginine-phosphorylated proteins |
-, 730385 |
| 3.9.1.2 | C9S |
mutation of active site cysteine, complete loss of activity |
728854 |
| 3.9.1.2 | D118A |
complete loss of activity |
729550 |
| 3.9.1.2 | F120A |
60fold reduction of specific activity |
729550 |
| 3.9.1.2 | T11I |
18fold reduction of specific activity with phospho-arginine substrates, marked increasing in the activity toward phospho-tyrosine substrates |
729550 |
| 3.9.1.2 | T11V |
18fold reduction of specific activity with phospho-arginine substrates, marked increasing in the activity toward phospho-tyrosine substrates |
729550 |
