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EC Number
Protein Variants
Commentary
Reference
3.6.1.29
H355N
inactive
-
,
713502
3.6.1.29
H96G
mutant Fhit can not hydrolyse phosphoanhydrides, but can synthetise dinucleoside tri- and tetraphosphates
655798
3.6.1.29
H96G
site-directed mutagenesis in the fragile histidine triad, leads to reduced activity and reduced hydrolysis of reaction intermediates
667612
3.6.1.29
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FHIT-specific small interference RNA transfection of SV40-immortalized normal bronchial BEAS cells that show levels of FHIT protein comparable to those of normal bronchial cells, results in a significant increase of TRAIL-induced apoptosis
699134
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