EC Number |
Protein Variants |
Reference |
---|
3.5.4.38 | C101S |
mutant lacks bth DNA and RNA deaminase activity |
754831 |
3.5.4.38 | C90A |
catalytically inactive |
719404 |
3.5.4.38 | E58Q/C87A/C90A |
the mutant enzyme does not bind to single-stranded DNA at all, though it retains some binding to RNA |
720139 |
3.5.4.38 | E72D |
mutant is moderately impaired in a ssDNA deamination assay but capable of RNA deamination |
754831 |
3.5.4.38 | G56N |
mutation at the N-terminus end of loop-3 does not bestow deamination activity |
755413 |
3.5.4.38 | H248S/H250S |
increase in the concentration of zinc does not increase deamination activity |
755413 |
3.5.4.38 | K352A/K355A/K358A |
the product formation of the mutant enzyme can not reach saturation even when the maximum protein concentration is obtained |
757437 |
3.5.4.38 | K52A |
2fold reduction in processivity |
756557 |
3.5.4.38 | more |
construction of segment swaps between activation-induced deaminase (AID) and APOBEC3G and determination of their mutational sequence specificity |
719342 |
3.5.4.38 | more |
generation of several enzyme-deficient Aicda-/- mice |
720915 |