EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.B7 | D114A |
mutant enzyme shows high rates of fluorescent synthetic peptide hydrolysis |
684968 |
| 3.4.24.B7 | D114A |
mutation induces enhanced affinity for the Ca2+ ion or an irreversible loss of enzymatic activity triggered by low-affinity calcium binding respectively |
684968 |
| 3.4.24.B7 | D165A |
very low rates of hydrolysis that are less than 5% of that seen for wild-type MMP-26 |
684968 |
| 3.4.24.B7 | E191A |
very low rates of hydrolysis that are less than 5% of that seen for wild-type MMP-26 |
684968 |
| 3.4.24.B7 | E209A |
inactive mutant enzyme |
684968 |
| 3.4.24.B7 | H81R |
mutation restores the conventional cysteine-switch in the prodomain but fails to induce the cysteine-swich activation |
652254 |
| 3.4.24.B7 | K189E |
calcium-independent high invasiveness is observed in the K189E mutant MDA-MB-231 cell line |
684968 |
| 3.4.24.B7 | K189E |
mutant enzyme shows high rates of fluorescent synthetic peptide hydrolysis |
684968 |
| 3.4.24.B7 | K189E |
mutation induces enhanced affinity for the Ca2+ ion or an irreversible loss of enzymatic activity triggered by low-affinity calcium binding respectively |
684968 |
| 3.4.24.B7 | more |
exchanging residues 88-123 of secretory MMP-7 with the same region in MMP-26 causes localization of this MMP-7 construct to the ER |
755387 |
