EC Number |
Protein Variants |
Reference |
---|
3.4.22.29 | 134Rstop |
intramolecular cleavage and cleavage of P8-P8' is completely abolished |
648054 |
3.4.22.29 | C101S |
intramolecular cleavage is reduced to 52% of that of the wild-type enzyme and cleavage of P8-P8' is reduced to 20% of that of the wild-type enzyme, cleavage of eIF4G is 75-100% of that of the wild-type enzyme |
648054 |
3.4.22.29 | C106S |
intramolecular cleavage and cleavage of P8-P8' is completely abolished |
648054 |
3.4.22.29 | C110A |
inactive |
732341 |
3.4.22.29 | C110S |
construction of catalytically inactive enzyme mutant EV71-2AC110S |
-, 755212 |
3.4.22.29 | C112S |
intramolecular cleavage and cleavage of P8-P8' is completely abolished, no detectable cleavage of eIF5G |
648054 |
3.4.22.29 | C138A |
intramolecular cleavage is reduced to 90% of that of the wild-type enzyme and cleavage of P8-P8' is reduced to 200% of that of the wild-type enzyme, cleavage of eIF4G is 75-100% of that of the wild-type enzyme |
648054 |
3.4.22.29 | C52A |
intramolecular cleavage and cleavage of P8-P8' is completely abolished, no detectable cleavage of eIF5G |
648054 |
3.4.22.29 | C54A |
intramolecular cleavage and cleavage of P8-P8' is completely abolished, no detectable cleavage of eIF5G |
648054 |
3.4.22.29 | C61A |
intramolecular cleavage is reduced to 54% of that of the wild-type enzyme and cleavage of P8-P8' is reduced to 40% of that of the wild-type enzyme, cleavage of eIF4G is 10-25% of that of the wild-type enzyme |
648054 |