EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.16 | C26S |
site-directed mutagenesis, catalytically inactive active site mutant |
755176 |
| 3.4.22.16 | C80S |
site-directed mutagenesis, the mutation removes the disulfide between the mini-chain and the mature domain and completely abolishes the protease activity |
755176 |
| 3.4.22.16 | H166A |
site-directed mutagenesis, catalytically inactive active site mutant |
755176 |
| 3.4.22.16 | more |
generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background |
-, 753961 |
| 3.4.22.16 | more |
lentiviral shRNA knockdown in human keratinocytes |
753961 |
| 3.4.22.16 | more |
mutant lacking the mini chain, loss of aminopeptidase activity, increase in endopeptidase activity |
650194 |
| 3.4.22.16 | more |
mutant lacking the mini-chain, T11_E18del-cathepsin H, minimal aminopeptidase activity against good wild type substrates, endopeptidase activity against Z-L-Phe-L-Arg-NH-4-methylcoumaryl-7-amide, which is not cleaved by wild type |
650475 |
| 3.4.22.16 | N186A |
site-directed mutagenesis, catalytically inactive active site mutant |
755176 |
| 3.4.22.16 | T83A |
site-directed mutagenesis, mutation of the Thr83 of the mini-chain has only mild effects on the enzyme activity |
755176 |
