EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.114 | D1129E |
mutant is able to cleave the Nsp4/5 site with wild-type efficiently but does not process the Nsp3/4 and Nsp5/6 junctions |
651859 |
| 3.4.21.114 | D1129K |
no Nsp3456 cleavage |
651859 |
| 3.4.21.114 | D1129V |
no Nsp3456 cleavage |
651859 |
| 3.4.21.114 | D64A |
site-directed mutagenesis, the mutant shows significantly reduced ability to induce apoptosis compared to the wild-type enzyme |
732736 |
| 3.4.21.114 | H1103G |
complete inhibition of Nsp3456 processing |
-, 651859 |
| 3.4.21.114 | H1103R |
complete inhibition of Nsp3456 processing |
-, 651859 |
| 3.4.21.114 | H1198L |
completely abolished processing of Nsp4/5 and Nsp5/6 |
651859 |
| 3.4.21.114 | H1198R |
completely abolished processing of Nsp4/5 and Nsp5/6 |
651859 |
| 3.4.21.114 | H1198Y |
completely abolished processing of Nsp4/5 and Nsp5/6 |
651859 |
| 3.4.21.114 | H39A |
site-directed mutagenesis, the mutant shows significantly reduced ability to induce apoptosis compared to the wild-type enzyme |
732736 |
