EC Number |
Protein Variants |
Reference |
---|
3.4.21.108 | A141S |
affects the enzymatic activity of the protease, associated with the development of Parkinsons disease |
686002 |
3.4.21.108 | A141S |
HtrA2 variant |
698176 |
3.4.21.108 | A141S |
missense mutation, mutation within the PDZ domain |
698185 |
3.4.21.108 | A141S |
mutation in HtrA2 identified in patients with Parkinson's disease |
689124 |
3.4.21.108 | A141S |
polymorphism associated with Parkinsons disease |
695598 |
3.4.21.108 | A144G |
mutation reduces ability to promote cell death, weak interaction with XIAP |
652331 |
3.4.21.108 | A147I |
increased affinity for the BIR3 domain of XIAP |
652331 |
3.4.21.108 | A227S |
HtrA2 variant |
698176 |
3.4.21.108 | E292A |
residue involved in most of the peptide interactions, about 30% of wild-type catalytic efficiency |
732718 |
3.4.21.108 | E296A |
residue involved in most of the peptide interactions, about 90% of wild-type catalytic efficiency |
732718 |