EC Number   |
Protein Variants |
Reference |
|---|
   3.4.17.10 | more |
a spontaneous Cpefat/fat mutant strain produces an inactive enzyme, which results in diminished cell survival after ischemic stress in the brain in vivo and in neuronal cells in vitro, overview |
669606 |
| 3.4.17.10 | more |
an N-terminal-truncated CPE/NF-alpha1 variant, a 40-kDa protein, is exclusively expressed in embryonic neurons |
753539 |
| 3.4.17.10 | more |
construction of deletion mutant of CPE |
667483 |
| 3.4.17.10 | more |
enzyme-defective CPEfat mice show elevated levels of secretogranin III and chromogranin A in the pituitary compensating for the lacking CPE sorting function, overview |
669586 |
| 3.4.17.10 | more |
metabolic analysis of female and male heterozygous and homozygeous enzyme-deficient mutant mice, CPEfat/fat, in comparison to the wild-type mice, the mutant mice show reduced pro-islet amyloid polypeptide processing activity and reduced levels of PC2-chaperone protein 7B2 and prohormone invertase PC2, but not PC1/3, in beta cells, overview |
668420 |
| 3.4.17.10 | more |
mutant mice lacking the enzyme and mutant mice with defective enzymes, Cpefat/fat and Cpefat/+ mutants, show abnormal electroretinography responses, overview |
-, 669934 |
| 3.4.17.10 | more |
the polymorphisms 801 C to T and 847 C to T are explored |
695406 |
| 3.4.17.10 | R283W |
naturally occurring genetic variant of the enzyme, the mutant shows altered kinetics, heat stability, and pH optimum, and a 50% reduced activity compared to the wild-type enzyme |
668816 |
| 3.4.17.10 | S202P |
enzyme-defective mutant CPEfat/fat mice show a point mutation in the coding region of the gene encoding the enzyme, and lack enzyme activity completely, which affects peptide processing the mutant mice |
668816 |
| 3.4.17.10 | S202P |
inactive mutant, mice without carboxypeptidase E activity are overweight |
683414 |
