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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.16.2DELTA317-496 an N-terminal truncated form, lacking 179 N-terminal residues of PRCP is constructed. The circular dichroism spectrum of the truncated mutant illustrates that it is structured with significant helical content as indicated by local minima at 220 and 208 nm. The main products of angiotensin III metabolized by the truncated mutant is angiotensin 2-7 plus phenylalanine as determined by LC-MS. Angiotensin I blockes the metabolism of angiotensin III by the truncated mutant. Km (mM) (Ala-Pro-4-nitroanilide) lower compared to wild-type 696003
Display the word mapDisplay the reaction diagram Show all sequences 3.4.16.2E112D E112D polymorphism in the PRCP gene is associated with blood pressure response to benazepril in Chinese hypertensive patients 708136
Display the word mapDisplay the reaction diagram Show all sequences 3.4.16.2E112D prolylcarboxypeptidase E112D (rs22988668) D allele along and jointly with chronic hypertension are associated with a significant increased risk of preeclampsia 683041
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