EC Number   |
Protein Variants |
Reference |
|---|
   3.2.1.18 | A160G |
site-directed mutagenesis, the mutant shows slightly reduced activity compared to the wild-type enzyme |
717641 |
| 3.2.1.18 | A160G/M87G/I105G |
site-directed mutagenesis, inactive mutant |
717641 |
| 3.2.1.18 | A284T |
the mutation decreases enzymatic activity |
751427 |
| 3.2.1.18 | D198N |
neuraminidase activity is 10% of wild-type value. IC50 for zanamivir is 5fold higher than wild-type value. IC50 for oseltamivir is 5.5fold higher than wild-type value |
681085 |
| 3.2.1.18 | D198N |
the mutation moderately affects the susceptibility to neuraminidase inhibitors |
730298 |
| 3.2.1.18 | D198N/H274Y |
the mutation confers reduced inhibition to zanamivir, oseltamivir, and peramivir |
730298 |
| 3.2.1.18 | D198N/R152K |
inactive |
730298 |
| 3.2.1.18 | D198N/R292K |
inactive |
730298 |
| 3.2.1.18 | D199E |
the mutant shows increased enzyme activity compared to the wild type enzyme |
751431 |
| 3.2.1.18 | D234N |
the mutation results in significantly lower levels of sialidase activity (25%) compared to the wild type and is associated with sialosis |
730767 |
