EC Number   |
Protein Variants |
Reference |
|---|
   3.2.1.143 | A874W |
the mutant shows about 45% activity compared to the wild type enzyme |
716339 |
| 3.2.1.143 | D253N |
decrease in catalytic activity |
679467 |
| 3.2.1.143 | D314A |
site-directed mutagenesis, the mutation impairs ARH3-dependent DNA damage repair |
754168 |
| 3.2.1.143 | D314E |
site-directed mutagenesis, poly(ADP-ribose) binding structures of wild-type and D314A mutant, overview |
754165 |
| 3.2.1.143 | D536N |
loss of catalytic activity |
679467 |
| 3.2.1.143 | D738N |
no enzymic activity, no structural effect of mutation |
663959 |
| 3.2.1.143 | D77N |
site-directed mutagenesis, the mutation impairs ARH3-dependent DNA damage repair |
754168 |
| 3.2.1.143 | D77N/D78N |
mutation abolishes the hydrolytic activity on O-acetyl-ADP-ribose |
682516 |
| 3.2.1.143 | D77N/D78N |
no enzymic activity, binding of ADP-ribose is similar to wild-type |
665741 |
| 3.2.1.143 | E112A |
site-directed mutagenesis, inactive mutant |
-, 754824 |
