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Results 1 - 9 of 9
EC Number Protein Variants Commentary Reference
Display the reaction diagram Show all sequences 3.1.4.55D164A 0.07% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55D187A 83% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55D54A 0.09% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55D80A 0.07% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55D80A inactive with substrate bis(p-nitrophenyl)phosphate 719851
Display the reaction diagram Show all sequences 3.1.4.55H200A 10% of wild-type activity, 6.33fold decrease in kcat/KM with substituted methyl phenylphosphate diesters with leaving group pKa values ranging from 4 to 8.4. With bis(pnitrophenyl)phosphate as a substrate, there is a 10fold decrease in kcat/KM, primarily the result of a large increase in KM. The nickel ion-activated H200A mutant displays a bell-shaped pH dependence for kcat/KM with pKa values comparable to those of the wild-type enzyme 721652
Display the reaction diagram Show all sequences 3.1.4.55H222A 14% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55H78A 0.3% of wild-type activity 721652
Display the reaction diagram Show all sequences 3.1.4.55T75A 3% of wild-type activity 721652
Results 1 - 9 of 9