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EC Number
Protein Variants
Commentary
Reference
3.1.4.46
D46A
mutant shows no activity
695040
3.1.4.46
E119A
mutant shows no activity
695040
3.1.4.46
E44A
mutant shows no activity
695040
3.1.4.46
H59A
relative activity: 1.39%
695040
3.1.4.46
K121A
relative activity: 4.7%
695040
3.1.4.46
medicine
GP-PDE plays a role in the regulation of cytoskeletal modification
665036
3.1.4.46
more
a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment
679873
3.1.4.46
more
expression of the individual central GDPD domain alone (48.8 kDa) or this domain in combination with the putative carbohydrate-binding domain (73.8 kDa). Both truncated derivatives have lost more than 98% activity in comparison to the full-length GDPD protein
751063
3.1.4.46
more
generation of a nonpolar hpd/glpQ mutant strain, that retains detectable mRNA expression of the upstream gene glpT, which is cotranscribed with hpd/glpQ
-
,
716983
3.1.4.46
more
overexpression of GD4 in HEK-293 cells does not induce neurite formation or a change change in cell morphology
694209
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