EC Number |
Protein Variants |
Reference |
---|
3.1.3.89 | D137A |
complete loss of activity |
722956 |
3.1.3.89 | D69A |
almost complete loss of activity |
722956 |
3.1.3.89 | D77A |
complete loss of activity |
722956 |
3.1.3.89 | D90A |
the mutant shows no activity |
749824 |
3.1.3.89 | E114A |
the mutant shows no activity |
749824 |
3.1.3.89 | E122A |
almost complete loss of activity |
722956 |
3.1.3.89 | E145A |
the mutant shows almost no activity |
749824 |
3.1.3.89 | E72A |
catalytically inactive. Structures complexed with Co2+ and either TMP or dAMP disclose the unusual binding mode of deoxyribonucleotides in the active site |
722956 |
3.1.3.89 | E93A |
the mutant shows almost no activity |
749824 |
3.1.3.89 | H111A |
the mutant shows slightly reduced activity compared to the wild type enzyme |
749824 |