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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86D360A/N362A the mutations completely eliminate enzyme activity toward 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and significantly decrease the dephosphorylation activity of the enzyme for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 751562
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86D608A catalytically inactive 751174
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86F593D/L597D the mutations largely mimic the absence of the C2 domain 750408
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86R649A the mutation removes C2 domain effects on inositol 1,3,4,5-tetrakisphosphate but not 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate kinetics 750408
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