EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.7 | D130A/H131A |
mutant fails to hydrolyze c-di-AMP |
-, 751993 |
| 3.1.3.7 | D141A |
less than 5% of the wild-type activity |
81105 |
| 3.1.3.7 | D141N |
less than 5% of the wild-type activity |
81105 |
| 3.1.3.7 | D144N |
less than 5% of the wild-type activity |
81105 |
| 3.1.3.7 | D201N |
8.2% relative activity compared to the wild type enzyme |
677833 |
| 3.1.3.7 | D292A |
less than 5% of the wild-type activity |
81105 |
| 3.1.3.7 | D292N |
less than 5% of the wild-type activity |
81105 |
| 3.1.3.7 | D363N |
6.2% relative activity compared to the wild type enzyme |
677833 |
| 3.1.3.7 | E133Q |
4.8% relative activity compared to the wild type enzyme |
677833 |
| 3.1.3.7 | E301K |
strongly reduced activity compared to the wild type enzyme |
677833 |
