EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.64 | C330S |
strong decrease in enzymatic activity (27% of wild type activity), mutant displays a similar localization pattern to the wild-type construct |
680079 |
| 3.1.3.64 | C336S |
inactive MTMR6 active site mutant |
646451 |
| 3.1.3.64 | C375S |
a phosphatase-dead mutant of MTM1 also localizes in early and late endosomes |
682936 |
| 3.1.3.64 | C375S |
inactive MTM1 mutant, catalytic cysteine |
646451 |
| 3.1.3.64 | C407S |
catalytically inactive |
750697 |
| 3.1.3.64 | C413S |
a dominant-negative inactive mutant of myotubularin-related phosphatase 3. The distribution of MTMR3C413S substantially overlaps with both autophagy-related PtdIns3P-binding proteins GST-2xFYVE and GFP-LC3, demonstrating that the amount of PtdIns3P is focally increased in areas of MTMR3C413S accumulation on autophagosomes |
716970 |
| 3.1.3.64 | C417S |
site-directed mutagenesis, a catalytically inactive MTMR2 variant |
715598 |
| 3.1.3.64 | C554S |
mutant does not show any activity |
732112 |
| 3.1.3.64 | D278A |
site-directed mutagenesis, inactive, substrate-trapping mutant |
665599 |
| 3.1.3.64 | D559N |
mutant does not show any activity |
732112 |
